Biological Actions of Prostacyclin and its Pharmacological use in Platelet Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

Salvador Moncada , Brendan J. R. Whittle

ABSTRACT

Prostacyclin is the predominant cyclo-oxygenase product of the essential fatty acid arachidonic acid in vascular tissues from animals and man. The ability of the walls of larger vessels to synthesize prostacyclin is greatest at the intimai surface and progressively decreases towards the adventitia (1). Studies on the biosynthesis of prostacyclin by cultured cells from vessel walls shows that the endothelial cells have the greatest capacity to produce prostacyclin (2,3). Prostacyclin relaxes isolated vascular strips and is a potent hypotensive agent through its induction of vasodilatation of all vascular beds studied, including the gastro-intestinal pulmonary and cerebral circulations (for review, see 4). Furthermore, several studies have suggested that prostacyclin generation participates in, or accounts for, functional hyperaemia in various vascular beds (5,6). More... »

PAGES

337-58

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-9442-0_24

DOI

http://dx.doi.org/10.1007/978-1-4615-9442-0_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031819942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3010671


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