Lymph Node Response to Antigen-Antibody Complexes and the Fate of Injected Primed Lymphocytes in a Tolerant Host View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1971

AUTHORS

B. M. Balfour , D. M. V. Parrott , J. H. Humphrey , M. de Sousa

ABSTRACT

The object of the present experiments was to investigate the origin of germinal center blast cells and to see whether an antigen trapped in germinal centers during an immune response played any part in the recruitment of cells from outside the primary nodule. We hoped to demonstrate this process, if indeed it had any reality, by taking lymph node cells from a donor primed against an antigen A (HSA) and transferring them into a recipient in whom that antigen, in the form of antigen-antibody complexes, had localized in the germinal centers of a particular lymph node. Furthermore, we arranged to have another antigen B (lysozyme) localized in the germinal centers of the contralateral node. In this situation we would expect the HSA primed cells to gather round the HSA and not the lysozyme complexes. Conversely, if we took cells primed against lysozyme they would gather round the lysozyme complexes (Fig. l). In order to ensure that no host cells would interfere with this phenomenon, we decided to use animals made tolerant to the antigen against which the cells had been primed. More... »

PAGES

235-241

Book

TITLE

Morphological and Functional Aspects of Immunity

ISBN

978-1-4615-9013-2
978-1-4615-9011-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-9011-8_31

DOI

http://dx.doi.org/10.1007/978-1-4615-9011-8_31

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030537195


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