Some Facts and Fancies Relating to Chromosome Structure in Man View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1977

AUTHORS

H. J. Evans

ABSTRACT

An understanding of the structure of the chromosome is often considered to be one of the major outstanding problems in biology, and is a problem which is currently attracting a great deal of interest. During the last 5 years or so, this understanding has been considerably improved as a consequence of the application of a variety of very different techniques and technical approaches. These include various special staining methods that preferentially delimit a variety of specific regions and bands along chromosomes and may, indeed, distinguish between chromatids containing all new and a mixture of old and new DNA; the location of particular DNA species through the use of the combined techniques of autoradiography and nucleic acid hybridization to chromosomes in situ; the application of techniques of DNA fractionation and use of specific nucleases to reveal patterns of DNA composition and arrangement; various methods for separating components within the histone and nonhistone proteins associated with the chromosomal DNA; and the use of X-ray diffraction, nuclear magnetic resonance spectrometry, and new techniques of electron microscopy to unravel some of the complexities of structure and organization of the DNA-protein complex in the chromosome. More... »

PAGES

347-438

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  • Book

    TITLE

    Advances in Human Genetics 8

    ISBN

    978-1-4615-8269-4
    978-1-4615-8267-0

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4615-8267-0_5

    DOI

    http://dx.doi.org/10.1007/978-1-4615-8267-0_5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014971685


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