Biodegradable Polymers for Sustained Drug Delivery View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1977

AUTHORS

A. Schindler , R. Jeffcoat , G. L. Kimmel , C. G. Pitt , M. E. Wall , R. Zweidinger

ABSTRACT

SynopsisMost studies of the sustained release of drugs from subdermally implanted polymer devices have centered on the use of silicone rubber. However, the use of this polymer has serious limitations because of its nonbiodegradability. The depleted capsule has to be surgically removed if one is to eliminate potential problems associated with non-degradable foreign substances remaining in the body for an indefinite length of time. The development of polymer systems which combine the release properties of silicone rubber with biodegradability will represent a significant advance in the technique of controlled release of contraceptives. The polymer system selected for our investigations were polyesters comprising homo and copolymers of glycolide, dilactide, ε-caprolactone, and ε-decalactone. These polymers were found to undergo random hydrolytic degradation under in vitro and in vivo conditions. The polymers were characterized by their rates of biodegradation and their release parameters for contraceptive steroids. Long time release rates of steroids from monolithic and reservoir devices were determined. Especially poly(ε-caprolactone) was found to come close to meeting the requirements of a biodegradable reservoir device for controlled drug delivery, with a useful lifespan approaching one year. Copolymers of ε-caprolactone and racemic dilactide are more permeable than poly(ε-caprolactone) and are of value for biodegradable devices with shorter than one year lifespan. More... »

PAGES

251-289

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-6737-0_12

DOI

http://dx.doi.org/10.1007/978-1-4615-6737-0_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046060222


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