Production of Metabolites of L-Deprenyl and pFluoro-L-Deprenyl in Rat Brain After Central Administration View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

A. Lajtha , H. Sershen , T. Cooper , A. Hashim , J. Gaal

ABSTRACT

L-Deprenyl (selegiline), a selective inhibitor of monoamine oxidase type B (MAO-B), has been used in the treatment of Parkinson’s disease (1) and was recently proposed for use in the treatment of neurodegenerative disorders (2). L-Deprenyl is rapidly metabolized to L-desmethyldeprenyl (DMD) and L-methamphetamine (MA) by oxidative demethylation and depropylation. DMD and MA are metabolized to amphetamine (A) by further oxidative demythylation and depropynylation (3). Reynolds et al. (3) were the first to report the biotransformation in man of deprenyl to A and MA, which are excreted in urine and can be detected in brain tissue. There has been some concern about these metabolites, in particular about the possible abuse potential of the amphetamine formed. However, the (−)-isomers of amphetamine derivatives have lower psychostimulant activity than the (+)-enantiomers, and the stereoisometric configuration persists during the metabolism of the drug; with no transformation into the (+)-form (4,5). More... »

PAGES

315-322

References to SciGraph publications

Book

TITLE

Neurochemistry

ISBN

978-1-4613-7468-8
978-1-4615-5405-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5405-9_53

DOI

http://dx.doi.org/10.1007/978-1-4615-5405-9_53

DIMENSIONS

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