Effects of Ammonia and L-Tryptophan Loading on Brain Extracellular 5-HT and 5-HIAA Levels in Chronic Experimental Hepatic Encephalopathy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

Peter B. F. Bergqvist , Stephan Hjorth , Robert M. Audet , Gustav Apelqvist , Roger F. Butterworth , Finn Bengtsson

ABSTRACT

Hepatic encephalopathy (HE) refers to a neuropsychiatric syndrome observed in patients with chronic liver failure. The pathogenesis for this important, but clinically often neglected, syndrome is still unknown. A profound perturbation in the handling of ammonia as well as of the essential aromatic amino acid L-tryptophan (L-TRP) has been shown to be associated with HE. This incapacity for normal L-TRP processing accompanying HE in vivo encompasses disturbances in L-TRP kinetics and metabolism both in brain tissue (1, for overview, see 2) as well as in the brain extracellular compartment (3,4). More... »

PAGES

201-207

References to SciGraph publications

Book

TITLE

Neurochemistry

ISBN

978-1-4613-7468-8
978-1-4615-5405-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5405-9_34

DOI

http://dx.doi.org/10.1007/978-1-4615-5405-9_34

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046882451


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