Muscarinic Receptors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

Tatsuya Haga , Kazuko Haga , Fumio Nakamura , Mariko Kato Hayashi , Kimihiko Kameyama , Hirofumi Tsuga

ABSTRACT

Muscarinic acetylcholine receptors are members of G protein-coupled receptor superfamily. All five subtypes (ml-m5) have putative seven transmembrane segments and are characterized with long third intracellular loops. The ml, m3, and m5 subtypes are linked with Gq family G proteins, and the m2 and m4 subtypes with Gi/Go family G proteins. Muscarinic receptors are known to be phosphorylated by cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and G protein-coupled receptor kinases (GRK) (see reviews (1,2)). The m2 receptor has been most extensively studied and is shown to be phosphorylated by PKA and GRK2, 3, 5 and 6. The m2 receptor of chicken heart is reported to be phosphorylated by PKC. Multiple sites are phosphorylated by each kinase. The ml receptor is known to be phosphorylated by PKC. The ml receptor is better substrate of PKC but poorer substrate of PKA compared with the m2 receptor. The ml receptor was recently shown to be phosphorylated by GRK2, as described later. The m3 receptor is reported to be phosphorylated by GRK2 and 3 (3). Recently a novel kinase, which phosphorylates a fusion protein containing a peptide corresponding to a part of the third intracellular loop of the m3 receptor, was purified from cerebellum (4). No direct evidence is available for phosphorylation of m4 and m5 receptors, as far as we know. More... »

PAGES

807-811

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5405-9_133

DOI

http://dx.doi.org/10.1007/978-1-4615-5405-9_133

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050624740


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