Intestinal cell cycle regulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

Tien C. Ko , Wade A. Bresnahan , E. Aubrey Thompson

ABSTRACT

The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-β, which is expressed in the gut epithelium. More... »

PAGES

43-52

Book

TITLE

Progress in Cell Cycle Research

ISBN

978-1-4613-7451-0
978-1-4615-5371-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5371-7_4

DOI

http://dx.doi.org/10.1007/978-1-4615-5371-7_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002596009


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