Recent Advances in the Discovery and Development of Flavonoids and their Analogues as Antitumor and Anti-HIV Agents View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Hui-Kang Wang , Yi Xia , Zheng-Yu Yang , Susan L. Morris Natschke , Kuo-Hsiung Lee

ABSTRACT

Antitumor and anti-HIV flavonoids and their analogues will be reviewed with emphasis on those discovered in our laboratory. The active antitumor compounds include the antileukemic tricin (1) and kaempferol-3-O-beta-D-glucopyranoside (2) from Wikstroemia indica, the cytotoxic hinokiflavone (3) from Rhus succedanea, the cytotoxic isoflavone (8) from Amorpha fruticosa, two dihydroxypentamethoxyflavones (9, 10) from Polanisia dodencandra. The development of synthetic 2-phenyl-4-quinolones as potent cytotoxic antimitotic flavonoid analogues and 2-phenylthiochromen-4-ones as potent antitumor flavonoid analogues will be presented. Selected results from other laboratories and antitumor-related biological studies also will be discussed. Flavonoids have also been investigated as potential anti-HIV agents. In our laboratory, acacetin-7-O-beta-D-galactopyranoside (131) from Chrysanthemum morifolium and chrysin (102), as well as apigenin-7-O-beta-D-glucopyranoside (130), from Kummerowia striata, have been found to exhibit anti-HIV activity. In other studies, some flavonoids and related compounds have been investigated as inhibitors of HIV-1 reverse transcriptase, protease, and integrase. The isolation and structural modification of such plant-derived active principles provide a continuing source of potential antitumor and anti-HIV agents. More... »

PAGES

191-225

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5335-9_15

DOI

http://dx.doi.org/10.1007/978-1-4615-5335-9_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024740362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9781305


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