Is the Sialic Acid Binding Activity of the S Protein Involved in the Enteropathogenicity of Transmissible Gastroenteritis Virus? View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

C. Krempl , H. Laude , G. Herrler

ABSTRACT

Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections. More... »

PAGES

557-561

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-5331-1_72

DOI

http://dx.doi.org/10.1007/978-1-4615-5331-1_72

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024258684

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9782329


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