Adoptive Immunotherapy Using Donor Leukocyte Infusions to Treat Relapsed Hematologic Malignancies after Allogeneic Bone Marrow Transplantation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

William R. Drobyski

ABSTRACT

Allogeneic bone marrow transplantation (BMT) is the only curative therapy for a number of patients with hematologic malignancies. The therapeutic efficacy of allogeneic marrow transplantation derives from the conditioning regimen which is myeloablative and the allogeneic marrow graft itself which is able to exert an antileukemic effect against residual malignant cell populations. This phenomenon which has been termed the graft-versus-leukemia (GVL) effect is mediated by immunocompetent cells resident in the donor marrow graft (1). Support for the existence of the GVL effect has come from both animal models (2,3) and epidemiological studies in man (4) which have provided strong evidence that allogeneic marrow transplantation is a potent demonstration of effective adoptive immunotherapy. More... »

PAGES

233-266

References to SciGraph publications

  • 1997-10. Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 1998-05. Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: equal efficacy of lymphocytes from sibling and matched unrelated donors in BONE MARROW TRANSPLANTATION
  • 1997-07. Induction of graft-versus-host disease as immunotherapy of leukemia relapsing after allogeneic transplantation: single-center experience of 32 adult patients in BONE MARROW TRANSPLANTATION
  • 1997-02. Adoptive immunotherapy for relapsed multiple myeloma after allogeneic bone marrow transplantation (BMT): evidence for a graft-versus-myeloma effect in LEUKEMIA
  • 1998-03. Generation of leukemia-reactive cytotoxic T lymphocytes from HLA-identical donors of patients with chronic myeloid leukemia using modifications of a limiting dilution assay in BONE MARROW TRANSPLANTATION
  • 1997-05. Donor lymphocyte infusions (DLI) in patients with chronic myeloid leukemia following allogeneic bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 1998-03. T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect in BONE MARROW TRANSPLANTATION
  • 1979-10. Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity in NATURE
  • 1997-04. Sequential molecular monitoring of chimerism in chronic myeloid leukemia patients receiving donor lymphocyte transfusion for relapse after bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 1997-05. Management of lymphoma recurrence after allogeneic transplantation: the relevance of graft-versus-lymphoma effect in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4615-4987-1_11

    DOI

    http://dx.doi.org/10.1007/978-1-4615-4987-1_11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049003293

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10800652


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