Regulation of Cerebral Oxygen Delivery View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

1999

AUTHORS

Fahmeed Hyder , Robert G. Shulman , Douglas L. Rothman

ABSTRACT

Under normal conditions, it is generally accepted that for the adult mammalian cortex, almost all the energy required for cerebral ATP generation is supplied by oxidation of glucose through the tri-carboxylic acid cycle (Siesjö, 1978), and cerebral metabolic rates of oxygen and glucose use (i.e., CMRO2 and CMRglc, respectively) are regionally modified to fulfil metabolic needs through regulation of cerebral blood flow (CBF) and volume (CBV) (Roy and Sherrington, 1890). However, some positron emission tomography (PET) results have reported that during brain activation of awake humans CBF increases by a greater fraction than CMRO2 (Fox and Raichle, 1986; Fox et al., 1988). In the last few decades, ever since in vivo cortical measurements could be made of CBF and/or CMRO2, the mechanisms for the proportionality of changes between CBF and CMRO2 due to physiological perturbations have remained intangible, and the measured stoichiometries have varied reflecting a variety of experimental methods and/or conditions. However, regionally tight relationship between CMRO2 and CBF has been observed at rest with a ratio of about ~1:1 (Kety et al., 1947–8; Raichle et al., 1976). More... »

PAGES

99-110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-4717-4_12

DOI

http://dx.doi.org/10.1007/978-1-4615-4717-4_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045790985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10659136


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemoglobins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxyhemoglobins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyder", 
        "givenName": "Fahmeed", 
        "id": "sg:person.01361711114.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361711114.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shulman", 
        "givenName": "Robert G.", 
        "id": "sg:person.011011752542.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011011752542.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothman", 
        "givenName": "Douglas L.", 
        "id": "sg:person.0660132734.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01955753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000026662", 
          "https://doi.org/10.1007/bf01955753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01955753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000026662", 
          "https://doi.org/10.1007/bf01955753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1919.sp001839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000106536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001612689", 
          "https://doi.org/10.1007/bf00585333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001612689", 
          "https://doi.org/10.1007/bf00585333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-2862(81)90094-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002645566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.1963.tb02652.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017194506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(93)90181-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(93)90181-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.1992.tb08055.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017819005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1993.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018827307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1993.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018827307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1890.sp000321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024339694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1995.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024828151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1995.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024828151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.75.1.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025725484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.4.1140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025818484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1893.sp000462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030049828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci104623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031759115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(90)91046-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032312001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(90)91046-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032312001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00581695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032937117", 
          "https://doi.org/10.1007/bf00581695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00581695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032937117", 
          "https://doi.org/10.1007/bf00581695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199701000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034707872", 
          "https://doi.org/10.1097/00004647-199701000-00009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199701000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034707872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199701000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034707872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034922839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034922839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1975.tb11881.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.4.1834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036058417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-6576.1975.tb05408.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036226614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199710000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036325226", 
          "https://doi.org/10.1097/00004647-199710000-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199710000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036325226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199710000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036325226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.35.3.483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042622026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9290(91)90348-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046753408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.15.7612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047389956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-197204000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049133758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-197204000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049133758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-2862(84)90059-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049656140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(85)83890-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050420691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1976.00500080001001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053305379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/99.3.523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059444952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3260686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062602706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.76.1.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063340459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.77.6.1201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063340724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.104.12.765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063457287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.37.1.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064366754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075212793", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1954.6.12.731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075518057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1959.197.6.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076519644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1992.262.5.h1515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077054711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1990.258.1.h80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077279880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079850606", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1996.270.2.h545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082952365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1996.81.2.885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082983211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1998.85.2.554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083299966"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999", 
    "datePublishedReg": "1999-01-01", 
    "description": "Under normal conditions, it is generally accepted that for the adult mammalian cortex, almost all the energy required for cerebral ATP generation is supplied by oxidation of glucose through the tri-carboxylic acid cycle (Siesj\u00f6, 1978), and cerebral metabolic rates of oxygen and glucose use (i.e., CMRO2 and CMRglc, respectively) are regionally modified to fulfil metabolic needs through regulation of cerebral blood flow (CBF) and volume (CBV) (Roy and Sherrington, 1890). However, some positron emission tomography (PET) results have reported that during brain activation of awake humans CBF increases by a greater fraction than CMRO2 (Fox and Raichle, 1986; Fox et al., 1988). In the last few decades, ever since in vivo cortical measurements could be made of CBF and/or CMRO2, the mechanisms for the proportionality of changes between CBF and CMRO2 due to physiological perturbations have remained intangible, and the measured stoichiometries have varied reflecting a variety of experimental methods and/or conditions. However, regionally tight relationship between CMRO2 and CBF has been observed at rest with a ratio of about ~1:1 (Kety et al., 1947\u20138; Raichle et al., 1976).", 
    "editor": [
      {
        "familyName": "Eke", 
        "givenName": "Andras", 
        "type": "Person"
      }, 
      {
        "familyName": "Delpy", 
        "givenName": "David T.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4615-4717-4_12", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2631215", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2492201", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": {
      "isbn": [
        "978-1-4613-7137-3", 
        "978-1-4615-4717-4"
      ], 
      "name": "Oxygen Transport to Tissue XXI", 
      "type": "Book"
    }, 
    "name": "Regulation of Cerebral Oxygen Delivery", 
    "pagination": "99-110", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10659136"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045790985"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4615-4717-4_12"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "da1f1c528322e82db09319e9cc7f5500897da08f070705aabdbcff0e4f7dec25"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4615-4717-4_12", 
      "https://app.dimensions.ai/details/publication/pub.1045790985"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T09:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130817_00000004.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-1-4615-4717-4_12"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-4717-4_12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-4717-4_12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-4717-4_12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-4717-4_12'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      23 PREDICATES      82 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4615-4717-4_12 schema:about N67dcce93da7949e5b4afc8e02577fda6
2 N7e469247fd8c4978b777053698cb48e5
3 N7f10cd34c3304ec2bf353b97e1ac7fe9
4 N90dc22887da84edc85ddff19ddd1cc75
5 Nc07405a8e4b44bcaad75ac291821d65a
6 Nc334d90270324191a26672eeb9d40428
7 Ncd1228e8c1c242259da3cc51a96b29d7
8 Nf7091482b72e428e889edc40270775ae
9 anzsrc-for:11
10 anzsrc-for:1109
11 schema:author N4bfb0fe42e714fe185b279d1ddf5f62a
12 schema:citation sg:pub.10.1007/bf00581695
13 sg:pub.10.1007/bf00585333
14 sg:pub.10.1007/bf01955753
15 sg:pub.10.1097/00004647-199701000-00009
16 sg:pub.10.1097/00004647-199710000-00005
17 https://app.dimensions.ai/details/publication/pub.1075212793
18 https://app.dimensions.ai/details/publication/pub.1079850606
19 https://doi.org/10.1001/archneur.1976.00500080001001
20 https://doi.org/10.1016/0006-8993(90)91046-j
21 https://doi.org/10.1016/0021-9290(91)90348-q
22 https://doi.org/10.1016/0026-2862(81)90094-7
23 https://doi.org/10.1016/0026-2862(84)90059-1
24 https://doi.org/10.1016/0304-3940(93)90181-j
25 https://doi.org/10.1016/s0006-3495(85)83890-x
26 https://doi.org/10.1038/jcbfm.1988.89
27 https://doi.org/10.1038/jcbfm.1993.113
28 https://doi.org/10.1038/jcbfm.1995.95
29 https://doi.org/10.1073/pnas.83.4.1140
30 https://doi.org/10.1073/pnas.93.15.7612
31 https://doi.org/10.1073/pnas.95.4.1834
32 https://doi.org/10.1093/brain/99.3.523
33 https://doi.org/10.1097/00000542-197204000-00015
34 https://doi.org/10.1097/00004647-199701000-00009
35 https://doi.org/10.1097/00004647-199710000-00005
36 https://doi.org/10.1111/j.1399-6576.1975.tb05408.x
37 https://doi.org/10.1111/j.1471-4159.1975.tb11881.x
38 https://doi.org/10.1111/j.1600-0404.1992.tb08055.x
39 https://doi.org/10.1111/j.1748-1716.1963.tb02652.x
40 https://doi.org/10.1113/jphysiol.1890.sp000321
41 https://doi.org/10.1113/jphysiol.1893.sp000462
42 https://doi.org/10.1113/jphysiol.1919.sp001839
43 https://doi.org/10.1126/science.3260686
44 https://doi.org/10.1152/ajpheart.1990.258.1.h80
45 https://doi.org/10.1152/ajpheart.1992.262.5.h1515
46 https://doi.org/10.1152/ajpheart.1996.270.2.h545
47 https://doi.org/10.1152/ajplegacy.1959.197.6.1205
48 https://doi.org/10.1152/jappl.1954.6.12.731
49 https://doi.org/10.1152/jappl.1996.81.2.885
50 https://doi.org/10.1152/jappl.1998.85.2.554
51 https://doi.org/10.1161/01.res.35.3.483
52 https://doi.org/10.1161/01.res.75.1.55
53 https://doi.org/10.1161/01.res.76.1.120
54 https://doi.org/10.1161/01.res.77.6.1201
55 https://doi.org/10.1172/jci104623
56 https://doi.org/10.1176/ajp.104.12.765
57 https://doi.org/10.1212/wnl.37.1.11
58 schema:datePublished 1999
59 schema:datePublishedReg 1999-01-01
60 schema:description Under normal conditions, it is generally accepted that for the adult mammalian cortex, almost all the energy required for cerebral ATP generation is supplied by oxidation of glucose through the tri-carboxylic acid cycle (Siesjö, 1978), and cerebral metabolic rates of oxygen and glucose use (i.e., CMRO2 and CMRglc, respectively) are regionally modified to fulfil metabolic needs through regulation of cerebral blood flow (CBF) and volume (CBV) (Roy and Sherrington, 1890). However, some positron emission tomography (PET) results have reported that during brain activation of awake humans CBF increases by a greater fraction than CMRO2 (Fox and Raichle, 1986; Fox et al., 1988). In the last few decades, ever since in vivo cortical measurements could be made of CBF and/or CMRO2, the mechanisms for the proportionality of changes between CBF and CMRO2 due to physiological perturbations have remained intangible, and the measured stoichiometries have varied reflecting a variety of experimental methods and/or conditions. However, regionally tight relationship between CMRO2 and CBF has been observed at rest with a ratio of about ~1:1 (Kety et al., 1947–8; Raichle et al., 1976).
61 schema:editor N9e475b2da4e546d9b26f47e4358f34af
62 schema:genre chapter
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf Nae6a7c811ab24f3394fe1ae20ca23a25
66 schema:name Regulation of Cerebral Oxygen Delivery
67 schema:pagination 99-110
68 schema:productId N1da47609e5774c3f9cf0c724f6cdc61a
69 N6b93d943ec24429e99b289b38ba7509e
70 N6c3dff1b4b88436ca22b48f8dbc424a3
71 Nf4abd7b60bce48ca81751d14ec6194b6
72 schema:publisher Nf5762a183b9a4d6689f83f27641a71aa
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045790985
74 https://doi.org/10.1007/978-1-4615-4717-4_12
75 schema:sdDatePublished 2019-04-16T09:17
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N1180149b4fb1492a9033682d730c1305
78 schema:url https://link.springer.com/10.1007%2F978-1-4615-4717-4_12
79 sgo:license sg:explorer/license/
80 sgo:sdDataset chapters
81 rdf:type schema:Chapter
82 N1180149b4fb1492a9033682d730c1305 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N1da47609e5774c3f9cf0c724f6cdc61a schema:name dimensions_id
85 schema:value pub.1045790985
86 rdf:type schema:PropertyValue
87 N4bfb0fe42e714fe185b279d1ddf5f62a rdf:first sg:person.01361711114.17
88 rdf:rest N5b6f95cd79804eeda2060ecdbcdae2f4
89 N5b6f95cd79804eeda2060ecdbcdae2f4 rdf:first sg:person.011011752542.00
90 rdf:rest Nd3c5baac3aec4cb2b5a030fcd1cb98bc
91 N67a4e662b5c340b788e1ceef22fdcfc4 schema:familyName Eke
92 schema:givenName Andras
93 rdf:type schema:Person
94 N67dcce93da7949e5b4afc8e02577fda6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Hemoglobins
96 rdf:type schema:DefinedTerm
97 N6b93d943ec24429e99b289b38ba7509e schema:name pubmed_id
98 schema:value 10659136
99 rdf:type schema:PropertyValue
100 N6c3dff1b4b88436ca22b48f8dbc424a3 schema:name doi
101 schema:value 10.1007/978-1-4615-4717-4_12
102 rdf:type schema:PropertyValue
103 N7e469247fd8c4978b777053698cb48e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Models, Biological
105 rdf:type schema:DefinedTerm
106 N7f10cd34c3304ec2bf353b97e1ac7fe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Oxygen
108 rdf:type schema:DefinedTerm
109 N90dc22887da84edc85ddff19ddd1cc75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Brain
111 rdf:type schema:DefinedTerm
112 N9e475b2da4e546d9b26f47e4358f34af rdf:first N67a4e662b5c340b788e1ceef22fdcfc4
113 rdf:rest Ndbd01385b0d44a809ab5527303b83dbe
114 Nae6a7c811ab24f3394fe1ae20ca23a25 schema:isbn 978-1-4613-7137-3
115 978-1-4615-4717-4
116 schema:name Oxygen Transport to Tissue XXI
117 rdf:type schema:Book
118 Nc07405a8e4b44bcaad75ac291821d65a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Rats
120 rdf:type schema:DefinedTerm
121 Nc334d90270324191a26672eeb9d40428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Animals
123 rdf:type schema:DefinedTerm
124 Ncd1228e8c1c242259da3cc51a96b29d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Oxyhemoglobins
126 rdf:type schema:DefinedTerm
127 Nd3c5baac3aec4cb2b5a030fcd1cb98bc rdf:first sg:person.0660132734.54
128 rdf:rest rdf:nil
129 Ndbd01385b0d44a809ab5527303b83dbe rdf:first Nf60ff2bb89f04696abbd185d9064d7b8
130 rdf:rest rdf:nil
131 Nf4abd7b60bce48ca81751d14ec6194b6 schema:name readcube_id
132 schema:value da1f1c528322e82db09319e9cc7f5500897da08f070705aabdbcff0e4f7dec25
133 rdf:type schema:PropertyValue
134 Nf5762a183b9a4d6689f83f27641a71aa schema:location Boston, MA
135 schema:name Springer US
136 rdf:type schema:Organisation
137 Nf60ff2bb89f04696abbd185d9064d7b8 schema:familyName Delpy
138 schema:givenName David T.
139 rdf:type schema:Person
140 Nf7091482b72e428e889edc40270775ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
147 schema:name Neurosciences
148 rdf:type schema:DefinedTerm
149 sg:grant.2492201 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4615-4717-4_12
150 rdf:type schema:MonetaryGrant
151 sg:grant.2631215 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4615-4717-4_12
152 rdf:type schema:MonetaryGrant
153 sg:person.011011752542.00 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
154 schema:familyName Shulman
155 schema:givenName Robert G.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011011752542.00
157 rdf:type schema:Person
158 sg:person.01361711114.17 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
159 schema:familyName Hyder
160 schema:givenName Fahmeed
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361711114.17
162 rdf:type schema:Person
163 sg:person.0660132734.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
164 schema:familyName Rothman
165 schema:givenName Douglas L.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54
167 rdf:type schema:Person
168 sg:pub.10.1007/bf00581695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032937117
169 https://doi.org/10.1007/bf00581695
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/bf00585333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001612689
172 https://doi.org/10.1007/bf00585333
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/bf01955753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000026662
175 https://doi.org/10.1007/bf01955753
176 rdf:type schema:CreativeWork
177 sg:pub.10.1097/00004647-199701000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034707872
178 https://doi.org/10.1097/00004647-199701000-00009
179 rdf:type schema:CreativeWork
180 sg:pub.10.1097/00004647-199710000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036325226
181 https://doi.org/10.1097/00004647-199710000-00005
182 rdf:type schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1075212793 schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1079850606 schema:CreativeWork
185 https://doi.org/10.1001/archneur.1976.00500080001001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053305379
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0006-8993(90)91046-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1032312001
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0021-9290(91)90348-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1046753408
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0026-2862(81)90094-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002645566
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0026-2862(84)90059-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049656140
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0304-3940(93)90181-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1017276155
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0006-3495(85)83890-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050420691
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1038/jcbfm.1988.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034922839
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1038/jcbfm.1993.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018827307
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1038/jcbfm.1995.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024828151
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1073/pnas.83.4.1140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025818484
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1073/pnas.93.15.7612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047389956
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.95.4.1834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036058417
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/brain/99.3.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059444952
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/00000542-197204000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049133758
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/00004647-199701000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034707872
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/00004647-199710000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036325226
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1399-6576.1975.tb05408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036226614
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1471-4159.1975.tb11881.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035512769
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1600-0404.1992.tb08055.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819005
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/j.1748-1716.1963.tb02652.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017194506
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1113/jphysiol.1890.sp000321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024339694
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1113/jphysiol.1893.sp000462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030049828
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1113/jphysiol.1919.sp001839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000106536
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1126/science.3260686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062602706
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1152/ajpheart.1990.258.1.h80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077279880
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1152/ajpheart.1992.262.5.h1515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077054711
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1152/ajpheart.1996.270.2.h545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082952365
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1152/ajplegacy.1959.197.6.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076519644
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1152/jappl.1954.6.12.731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075518057
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1152/jappl.1996.81.2.885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082983211
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1152/jappl.1998.85.2.554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083299966
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1161/01.res.35.3.483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042622026
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1161/01.res.75.1.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725484
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1161/01.res.76.1.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063340459
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1161/01.res.77.6.1201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063340724
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1172/jci104623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031759115
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1176/ajp.104.12.765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063457287
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1212/wnl.37.1.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064366754
262 rdf:type schema:CreativeWork
263 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
264 schema:name Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
265 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...