Ifn-γ Activated Indoleamine 2,3-Dioxygenase Activity in Human Cells is an Antiparasitic and an Antibacterial Effector Mechanism View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

Walter Däubener , Colin R. MacKenzie

ABSTRACT

In nearly all human cells IFN-gamma stimulation leads to an activation of indoleamine 2,3-dioxygenase (IDO) activity, which is responsible for anti-toxoplasma and anti-chlamydia effects. We have recently shown that IDO activation is also a defense mechanism against extracellular beta-hemolytic streptococci groups A, B, C and G in human glioblastoma cells, fibroblasts and macrophages. Similar effects were also seen with enterococci and in approximately 65% of staphylococci tested, including multiresistant strains of both species. In addition, we have found that IDO activity is differentially regulated in different cells. For example we have found that TNF-alpha enhances IFN-gamma induced IDO activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by TNF-alpha as well as by IL-1 in a human uroepithelial cell line. We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma-induced IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase. In human astrocytoma cells, IL-1 and TNF-alpha did not inhibit IDO activity and in concordance with this finding these cells did not show a detectable nitric oxide production. More... »

PAGES

517-524

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-4709-9_64

DOI

http://dx.doi.org/10.1007/978-1-4615-4709-9_64

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040314163

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10721095


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