Protein Kinases that Mediate Redox-Sensitive Signal Transduction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000

AUTHORS

Bradford C. Berk

ABSTRACT

Reduction-oxidation (redox) reactions that generate reactive oxygen species (ROS) have been identified as important chemical processes that regulate signal transduction. In this chapter ROS will refer to hydrogen peroxide (H2O2), Superoxide (O2-) and OH*. Because increased ROS may be a risk factor for cardiovascular events such as unstable angina, myocardial infarction and sudden death, understanding the biological processes that generate ROS and the intracellular signals elicited by ROS will be important to gain insight into the pathogenesis of these diseases. In this review, the role of the mitogen-activated protein (MAP) kinase pathway in redox-sensitive signal transduction, and the nature of the tyrosine kinases that act as proximate “sensors” for redox-mediated signal events are presented. Four major points will be discussed as they relate to the nature of redox sensitive signal events. 1) Signal transduction will differ when ROS generation is intracellular versus extracellular. Also extracellular generation is usually acute and related to ischemia/reperfusion settings, while intracellular generation is usually chronic and related to stimulation of cell metabolism. 2) There are species specific differences in generation and response to ROS. 3) Because of different reactions, the three primary ROS species will exert different effects on intracellular signals. 4) Signal pathways that are redox sensitive may be defined by specific activation of upstream mediators which include phospholipases, small G proteins and tyrosine kinases. The mechanisms by which these mediators regulate gene transcription are then discussed to provide insight into the pathogenic roles of ROS in hypertension, atherosclerosis and vascular remodeling. More... »

PAGES

335-348

Book

TITLE

Oxidative Stress and Vascular Disease

ISBN

978-1-4613-7103-8
978-1-4615-4649-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-4649-8_18

DOI

http://dx.doi.org/10.1007/978-1-4615-4649-8_18

DIMENSIONS

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