Growth factors regulating normal and malignant melanocytes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Ruth Halaban

ABSTRACT

Growth factors and growth factor receptors play a critical role in normal growth and development, and their aberrant expression and/or activity has been implicated in neoplastic transformation. A common characteristic of transformed cells is an acquired independence from environmental growth factors that are needed for the proliferation of the nontransformed cell. Such autonomy can be achieved at the level of the growth factor itself, the growth factor receptor, or molecules involved in the transduction of the mitogenic signal from the cell membrane to the nucleus. For example, aberrant, unregulated production of transforming growth factors (TGF-α and TGF-β) [1–3], platelet-derived growth fator (PDGF) [4,5], interleukins (IL-1, IL-2, and IL-3) [6–10], and epidermal growth factor (EGF) [11] with an induction of an autocrine loop was implicated in the maintenance of the transformed state of the respective target cells. Overexpression of the macrophage-colony stimulating factor (M-CSF) receptor, the EGF receptor, receptors homologous to the EGF receptor, or mutations that confer constitutive activity on the receptors have been shown to be oncogenic [12–17]. Several known retroviral oncogenes, such as v-erb-B, v-erb-A, fms, and neu, are transduced cellular genes encoding, respectively, the receptors for EGF, thyroid hormone (T3), macrophage colony stimulating factor (M-CSF), and an as-yet unidentified ligand [18–26]. Therefore, knowledge of the growth factor depencdency of the normal cell may be afirst step in the identification of a gene or genes expressed aberrantly in the malignent counterpart. Following is an up-to-date summary of the growth factors that are mitogenic for normal human melanocytes and their expression in melanoma cells. More... »

PAGES

19-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3938-4_2

DOI

http://dx.doi.org/10.1007/978-1-4615-3938-4_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028850915

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1673857


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