Glucocorticoid regulation of rRNA synthesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Pramod B. Mahajan , E. Aubrey Thompson

ABSTRACT

Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I. The data indicate that TFIC is a bonafide initiation factor that is required for formation of the first phosphodiester bond of nascent pre-rRNA. Extracts from dexamethasone-treated cells are devoid of this factor and cannot form initiated complexes in vitro. More... »

PAGES

195-200

Book

TITLE

Molecular Mechanisms of Cellular Growth

ISBN

978-1-4613-6733-8
978-1-4615-3886-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3886-8_24

DOI

http://dx.doi.org/10.1007/978-1-4615-3886-8_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036495297


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