Polymers as Stabilizers of Lipid Vesicles View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Tamotsu Kondo , Yutaka Atsuta , Atsushi Kato , Koichiro Fukuda , Hiroyuki Ohshima

ABSTRACT

Poly(acrylic acid) and carboxymethylchitin, respectively, were used to stabilize dipalmitoylphosphatidylcholine and egg yolk phosphatidylcholine vesicles in the micrometer range through complexation with the vesicle membranes. The stability of poly(acrylic acid)-complexed dipalmitoylphosphatidylcholine vesicles, as estimated by the release of a fluorescent marker into the surrounding medium, was found to depend on temperature as well as pH, ionic strength, and glucose concentration of the medium. These vesicles were quite stable to the action of various proteins, with no leak of the marker. On the other hand, carboxymethylchitin-complexed phosphatidylcholine vesicles were disintegrated to a certain extent through the interaction with serum albumin, while they were very resistant to serum globulins and fibrinogen. The vesicles were decomposed by the action of phospholipase C, an enzyme which can digest phosphatidylcholine, with remarkable release of the vesicle content. Phagocytosis of the vesicles by guinea-pig polymorphonuclear leucocytes was low, suggesting a high possibility that the vesicles when loaded with hemoglobin can be used as artificial red blood cells. More... »

PAGES

225-230

Book

TITLE

Cosmetic and Pharmaceutical Applications of Polymers

ISBN

978-1-4613-6722-2
978-1-4615-3858-5

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3858-5_23

DOI

http://dx.doi.org/10.1007/978-1-4615-3858-5_23

DIMENSIONS

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