Correlation Belween Second-Messenger Activities and Cerebral Blood Flow in the Basal Ganglia and Hippocampus after Unilateral Carotid Artery Occlusion in ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

K. Tanaka , F. Gotoh , Y. Fukuuchi , S. Gomi , S. Takashima , B. Mihara , T. Shirai , S. Nogawa , E. Nagata

ABSTRACT

We reported previously that cerebral ischemia for 6 h induced a significant reduction of forskolin (FK) binding over extensive brain regions, whereas the phorbol 12, 13-dibutyrate. (PDBu) binding was relatively well preserved in various cerebral structures1. These findings suggest that the adenylate cyclase (AC) system may be vulnerable In ischemic insult, while the protein kinase C (PKC) system may be relatively resistant to ischemia. The quantitative aUlnradiographic method employed previously1 permitted us to measure the regional FK and PDBu bindings and cerebral blood flow (CBF) in the same brain, so that the interrelationship between these three parameters could be precisely analyzed in each cerebral region. The basal ganglia including the caudateputamen (striatum) and hippocampus are known to be highly vulnerable to ischemia2, and these structures formed the focus of the present study on cerebral ischemia. The aim of this communication is to report the correlation between the second-messenger activities and CBF in the basal ganglia and hippocampus in 6-hour ischemia of the gerbil brain. More... »

PAGES

233-239

Book

TITLE

The Role of Neurotransmitters in Brain Injury

ISBN

978-1-4613-6528-0
978-1-4615-3452-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3452-5_35

DOI

http://dx.doi.org/10.1007/978-1-4615-3452-5_35

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043185796


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