Leukotrienes and Asthma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

J. Rokach , M. Barth , T. Bach , M. Belley , E. Champion , C. Chan , L. Charette , S. Charleson , R. N. DeHaven , D. Denis , R. Dixon , G. Eiermann , D. Ethier , J. Evans , A. W. Ford-Hutchinson , R. Fortin , A. Foster , R. Frenette , J. Y. Gauthier , J. Gillard , Y. Girard , Y. Guidon , P. Hamel , S. Hopple , J. Humes , L. Hupe , T. R. Jones , S. Leger , C. Leveillé , A. Lord , S. Luell , P. Masson , C. S. McFarlane , D. E. Mc McIntyre , J. Metzger , R. Meurer , D. Miller , H. E. Morton , E. Opas , S. Pacholok , L. Peterson , H. Piechuta , S. S. Pong , D. Riendeau , C. Rouzer , H. Williams , R. Young , C. Yoakim , R. Zamboni

ABSTRACT

The peptide leukotrienes LTC4, D4 and E4 collectively account for the biological activity known as slow-reacting substance of anaphylaxis (SRS-A). These metabolites of arachidonic acid are thought to play a role in lung pathophysiology. A role in asthma is postulated as a result of their potent bronchoconstrictor activity both in vitro (Dahlén et al. 1980; Drazen et al. 1980; Hanna et al. 1981; Piper et al. 1981; Jones et al. 1982; Peters et al. 1984) and in vivo (Manning et al. 1990; Holroyde et al. 1981; Griffin et al. 1983; Weiss et al. 1982; Barnes et al. 1984). Increased production of leukotrienes has been demonstrated following antigen challenge of the airways of allergic patients in vivo (Creticos et al. 1984; Ishihara et al. 1985; Isono et al. 1985) and in vitro (Dalhén et al. 1983). More... »

PAGES

93-103

Book

TITLE

Asthma Treatment

ISBN

978-1-4613-6525-9
978-1-4615-3446-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3446-4_8

DOI

http://dx.doi.org/10.1007/978-1-4615-3446-4_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050884545


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