The Dialysis Encapsulation Process: The Role of Endocytosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

Kathleen Andrews , Robert E. Droleskey , Laura Chiarantini , John R. DeLoach

ABSTRACT

Encapsulation by hypotonic dialysis is thought to be a diffusion process in which pores or small holes appear in the membrane when erythrocytes are under reduced osmotic pressure.’ These pores can remain open for days under appropriate conditions.2–4 Yet, under other conditions, encapsulation may occur through a process called endocytosis. Endocytosis can be induced by exposure to certain membrane-active drugs like primaquine, hydrocortisone, and chlorpromazine.5–7 It is also a phenomenon that occurs naturally;5,8,9 vacuoles frequently and spontaneously appear in neonatal erythrocytes.7–8 Endocytosis is also seen in erythrocytes of splenectomized people or when patients are functionally asplenic as in sickle cell anemia.5 Endocytic vacuoles can also form after hypoosmotic dilution by loading the mature erythrocytes with Mg2+, Ca2+, and ATP through the membrane holes.10 More... »

PAGES

63-71

Book

TITLE

The Use of Resealed Erythrocytes as Carriers and Bioreactors

ISBN

978-1-4613-6321-7
978-1-4615-3030-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-3030-5_8

DOI

http://dx.doi.org/10.1007/978-1-4615-3030-5_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043808499


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