Regulation of IGFBP-4 and -5 Expression in Rat Granulosa Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Xin-Jun Liu , Nicholas Ling

ABSTRACT

One of the central questions in reproductive physiology concerns how follicles in the ovary are selected during folliculogenesis. Although it has been well established that folliculogenesis is initiated and maintained by the gonadotropin, follicle-stimulating hormone (FSH), how follicle selection takes place in the ovary is still an enigma.1 Based on the notion that selection of the dominant follicle might be due to the action of a locally produced inhibitor in the follicular fluid which could block the effects of FSH on the non-selected follicles, our laboratory initiated a project in 1988 to isolate and identify the FSH inhibitor present in porcine ovarian follicular fluid. Using a well-defined rat granulosa cell culture assay to monitor the purification, a polypeptide was isolated which exhibited a potent inhibition of FSH-stimulated estradiol production in those cells.2 Chemical characterization of the inhibitor, however, revealed that its structure corresponded to insulin-like growth factor binding protein-3 (IGFBP-3).3 Subsequent studies carried out by our laboratory identified that the rat ovary produced five IGFBPs in a tissue-specific manner, with the mRNA for IGFBP-2 mainly expressed by theca interstitial cells, IGFBP-3 by luteinized granulosa cells, IGFBP-4 by the granulosa of atretic antral follicles, IGFBP-5 by the granulosa of atretic preantral follicles and IGFBP-6 by the theca externa, stroma and smooth muscle cells4–6. IGFBP-1 was not detected in the rat ovary. These findings indicate that the transcription of each IGFBP gene is regulated differently in the rat ovary and that each IGFBP may have a different physiological function. This hypothesis is strengthened by our finding that exogenously added IGFBP-2, -3, -4 and -5 were able to attenuate the FSH-stimulated production of estradiol and progesterone in cultured rat granulosa cells7,8 and ovarian intrabursal injection of IGFBP-3 was able to decrease the ovulation rate of pregnant mare’s serum gonadotropin/human choriogonadotropin-primed animals.9 More... »

PAGES

367-76

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-2988-0_34

DOI

http://dx.doi.org/10.1007/978-1-4615-2988-0_34

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048817643

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7514346


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