Regulation of Human Immunodeficiency Virus Structural Protein Expression and Virion Formation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Hans-Georg Kräusslich

ABSTRACT

The replication cycle of retroviruses, and in particular of complex retroviruses like human immunodeficiency virus (HIV), encompasses several unusual or unique features. After adsorption and penetration of the infecting virus, the viral plus-stranded RNA genome is reverse transcribed into a linear double-stranded cDNA which is integrated into the host cell genome as a provirus. While these early replication steps are mainly achieved by the action of viral enzymes associated with the incoming virion, transcription of the integrated provirus is performed by cellular polymerase II complexes. In the case of the simple animal retroviruses, cytoplasmic concentration of viral mRNAs is mainly regulated by host cell transcription control and by incomplete splicing of the primary transcript which also serves as the genomic RNA. Complex retroviruses, on the other hand, provide a multitude of cis-acting elements and trans-acting factors which regulate gene expression at a transcriptional and/or post-transcriptional level. In contrast to these transcriptional and post-transcriptional control mechanisms which have been scrutinized extensively in recent years, the late stages of assembly and maturation of infectious progeny virus are poorly understood. The structural proteins of the virion are synthesized as polyproteins which are transported to the plasma membrane via different cellular pathways. The various protein components and the genomic RNA congregate at the site of assembly leading to the formation of the viral bud and the extrusion of an immature virion. Proteolytic cleavage of structural polyproteins to yield the functional components is achieved by the viral proteinase and occurs predominantly after all virion components are confined in the assembled particle. Given the complexity of this assembly mechanism, it appears likely that, besides the regulation of mRNA synthesis, regulation of virion assembly provides an additional control mechanism in viral replication which may also serve as an important target for the development of novel antiviral compounds. More... »

PAGES

81-92

Book

TITLE

Regulation of Gene Expression in Animal Viruses

ISBN

978-1-4613-6271-5
978-1-4615-2928-6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-2928-6_7

DOI

http://dx.doi.org/10.1007/978-1-4615-2928-6_7

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53 schema:description The replication cycle of retroviruses, and in particular of complex retroviruses like human immunodeficiency virus (HIV), encompasses several unusual or unique features. After adsorption and penetration of the infecting virus, the viral plus-stranded RNA genome is reverse transcribed into a linear double-stranded cDNA which is integrated into the host cell genome as a provirus. While these early replication steps are mainly achieved by the action of viral enzymes associated with the incoming virion, transcription of the integrated provirus is performed by cellular polymerase II complexes. In the case of the simple animal retroviruses, cytoplasmic concentration of viral mRNAs is mainly regulated by host cell transcription control and by incomplete splicing of the primary transcript which also serves as the genomic RNA. Complex retroviruses, on the other hand, provide a multitude of cis-acting elements and trans-acting factors which regulate gene expression at a transcriptional and/or post-transcriptional level. In contrast to these transcriptional and post-transcriptional control mechanisms which have been scrutinized extensively in recent years, the late stages of assembly and maturation of infectious progeny virus are poorly understood. The structural proteins of the virion are synthesized as polyproteins which are transported to the plasma membrane via different cellular pathways. The various protein components and the genomic RNA congregate at the site of assembly leading to the formation of the viral bud and the extrusion of an immature virion. Proteolytic cleavage of structural polyproteins to yield the functional components is achieved by the viral proteinase and occurs predominantly after all virion components are confined in the assembled particle. Given the complexity of this assembly mechanism, it appears likely that, besides the regulation of mRNA synthesis, regulation of virion assembly provides an additional control mechanism in viral replication which may also serve as an important target for the development of novel antiviral compounds.
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