Clinical Efficacy of Desmopressin and Consistency of Responses to Separate Infusion in Patients with Prolonged Bleeding time Due to Congenital ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Giancarlo Castman , Francesco Rodeghiero

ABSTRACT

Desmopressin (DDAyP) is able to shorten or normalize the prolonged bleeding time (BT) in the majority of patients with von Willebrand disease (vWD) by inducing an increase of factor VIII/von Willebrand factor measurements in plasma through mechanisms still unknown1. Recently, this agent proved also successful in correcting the BT and in the prevention of bleeding in several platelet function defects2- 5, with the exception of Glanzmann Thrombasthenia2, 6, and in patients with prolonged BT of undefined etiology7. The precise mechanism by which DDAVP acts in these disorders remains elusive. Despite several patients with congenital platelet disorders have been infused with DDAVP for experimental purpose, clinical experience is still limited. Moreover, it is not established if the response to the drug, in terms of BT correction, is consistent in time. If this holds true, a test-infusion with DDAVP could predict the usefulness of the drug in the individual patient. More... »

PAGES

169-175

Book

TITLE

Desmopressin in Bleeding Disorders

ISBN

978-1-4613-6268-5
978-1-4615-2922-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-2922-4_19

DOI

http://dx.doi.org/10.1007/978-1-4615-2922-4_19

DIMENSIONS

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