Distribution of Endothelin, a Putative Growth Promoting Peptide, Using Modern Microscopical Imaging Methods View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Julia M. Polak , Giorgio Terenghi

ABSTRACT

The concept that endothelial cells in culture can produce a vasoconstrictor substance and secrete it into their medium was followed by the remarkable discovery in 1988 by Yanagisawa and colleagues 1 of a very potent vasoconstrictory peptide which they termed endothelin. This original work is an example of scientific excellence, combining molecular biology, cellular biology and pharmacological expertise to demonstrate that this active peptide is composed of 21 amino acids with two disulfide bonds, derives from a larger precursor termed preproendothelin and produces very marked and sustained vasoconstriction. This initial discovery led to a large number of further publications dealing with the identification of several endothelin peptide isoforms and the genes that encode them, regional variations in endothelin distribution, synthetic pathways for endothelins, multiple endothelin receptor subtypes and their genes, diverse endothelin receptor-coupled signal transduction pathways, numerous physiological effect of endothelins and alterations in endothelin levels associated with disease 2. More... »

PAGES

3-13

Book

TITLE

Growth Factors, Peptides and Receptors

ISBN

978-0-306-44484-5
978-1-4615-2846-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-2846-3_1

DOI

http://dx.doi.org/10.1007/978-1-4615-2846-3_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030443117


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