Fgf-3, an oncogene in murine breast cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

C Dickson , V Fantl

ABSTRACT

Cancer originates from cells that have acquired a succession of genetic changes that progressively enable them to proliferate outside the constraints of normal growth control. The earliest changes are considered to impinge on very few or even single cells, providing them with a growth advantage that facilitates their clonal expansion, and leads to the production of a significant population of cells that can act as a target for secondary mutations. Thus genetic alterations that have been envisaged may result in the inappropriate induction of potent cell signaling molecules that function as growth factors and/or promote neovascularization, the loss of functions that normally inhibit cell proliferation, and the induction of enzymes that can affect tissue remodeling. The basis for this conceptual framework, and the identification of candidate gene products involved in neoplastic transformation, has arisen in large part from the study of tumors in animal systems. More... »

PAGES

331-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-2592-9_18

DOI

http://dx.doi.org/10.1007/978-1-4615-2592-9_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038243491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7946957


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