The Role of Surface CD4 in HIV-Induced Apoptosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

Jacques Corbeil , Douglas D. Richman

ABSTRACT

The decline in CD4+ T lymphocytes is one of the hallmarks of HIV infection (Levy, 1993; Rosenberg and Fauci,1991; Stein et al.,1992). A number of studies have found that the level of virus replication in asymptomatic infection is greater than previously thought and HIV may directly account for a significant proportion of the CD4+ T cell depletion seen in AIDS (Embretson et al., 1993; Pantaleo et al. 1993; Piatak et al.,1993; Scadden et al., 1992). HIV-induced apoptosis may be an important contributor to this depletion. Several mechanisms have been proposed to explain how HIV-1 infection may lead to apoptotic cell death (Ameisen and Capron,1991; Banda et al.,1992; Gougeon et al., 1993a; Groux et al., 1992; Laurent-Crawford et al., 1991; Meyaard et al., 1992; Terai et al., 1991); however, some uncertainty remains concerning the conditions that trigger this process and if the target cells needs to be HIV-infected (Ameisen, 1992; Cohen, 1993; Gougeon et al., 1993b; Gougeon and Montagnier, 1993; Weiss, 1993). More... »

PAGES

91-99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1995-9_8

DOI

http://dx.doi.org/10.1007/978-1-4615-1995-9_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046021261

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7572403


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