Clonal Expansion of T Cells and HIV Genotypes in Microdissected Splenic White Pulps Indicates Viral Replication in Situ and Infiltration ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

Rémi Cheynier , Sven Henrichwark , Fabienne Hadida , Eric Pelletier , Eric Oksenhendler , Brigitte Autran , Simon Wain-Hobson

ABSTRACT

Human immunodeficiency virus (HIV) replication and T cell proliferation was investigated in situ by a PCR based analysis of individual microdissected splenic white pulps. Founder effects, revealed by an exquisite compartmentalization of HIV genotypes and T cells, indicated the recruitment of latently infected CD4+ T cells through highly localized antigen presentation, rather than the infection of CD4+ T lymphoblasts by blood borne virus or immune complexes. HIV infected white pulps could be infiltrated by HIV specific cytotoxic T lymphocytes, so implicating them in CD4+ T cell destruction in vivo. Together these data describe an iterative and deleterious mechanism of antigen driven T cell recruitment and activation, HIV replication and spread, with consequent destruction of the newly infected cells. More... »

PAGES

173-182

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1995-9_15

DOI

http://dx.doi.org/10.1007/978-1-4615-1995-9_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049186415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7572391


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1995-9_15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1995-9_15'


 

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