Human Epidermal Langerhans Cells Efficiently Present HIV-1 Antigens to Specific T Cell Lines View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

Giampiero Girolomoni , Maria Teresa Valle , Valentina Zacchi , Maria Grazia Costa , Alberto Giannetti , Fabrizio Manca

ABSTRACT

Dendritic cells (DC) play a dominant role in T cell priming both in vitro and in vivo. We have shown that peripheral blood (PB) DC are the most efficient APC for presentation of the HIV-1 envelope glycoprotein gpl20 to specific CD4+ T cells and are required for in vitro generation of gp120-specific T cell lines from unprimed individuals1. Epidermal DC, i.e. Langerhans cells (LC), are the critical APC for the induction of T cell immunity against Ag that are present in or penetrate through squamous epithelia2. LC obtained from HIV-infected subjects contain HIV-1 proviral DNA and RNA3, and can release HIV virions, thus indicating that LC are productively infected by the virus in vivo. More... »

PAGES

473-475

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1971-3_106

DOI

http://dx.doi.org/10.1007/978-1-4615-1971-3_106

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037851528

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8526121


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