Interaction of a Sulfhydryl Analogue of Vasoactive Intestinal Peptide (VIP) with Murine Lymphocytes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

C. A. Ottaway

ABSTRACT

Vasoactive intestinal peptide (VIP) is a 28 amino acid neuropeptide with potent immunoregulatory properties.1 The cDN A of the VIP receptor (VIPR) of NALM-6 cells predicts a heptahelical polypeptide chain homologous to other G-protein coupled neurotransmitter receptors.2 The predicted structure of VIPR includes two cysteine residues which are conserved in this receptor family. These are represented at positions 117 and 196 of the VIPR2 and positions 106 and 184 of the hamster beta-adrenergic receptor (BAR).3 Selective replacement of either of these cysteine residues4 in BAR alters the ligand binding properties of the receptor, and a disulfide bond between these residues on adjacent extracellular loops has been implicated in the maintenance of the conformational and functional integrity of the BAR ligand binding site.3,4 The purpose of this work was to examine the ability of lymphocytes to recognize and respond to an analogue of VIP in which cysteine was substituted for serine in the second position of the neuropeptide. More... »

PAGES

553-558

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1941-6_116

DOI

http://dx.doi.org/10.1007/978-1-4615-1941-6_116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013788219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8525988


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "1-Methyl-3-isobutylxanthine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzodiazepinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Concanavalin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Devazepide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesentery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Vasoactive Intestinal Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasoactive Intestinal Peptide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Toronto, M5S 1A8, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medicine, University of Toronto, M5S 1A8, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ottaway", 
        "givenName": "C. A.", 
        "id": "sg:person.0577250161.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577250161.89"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1995", 
    "datePublishedReg": "1995-01-01", 
    "description": "Vasoactive intestinal peptide (VIP) is a 28 amino acid neuropeptide with potent immunoregulatory properties.1 The cDN A of the VIP receptor (VIPR) of NALM-6 cells predicts a heptahelical polypeptide chain homologous to other G-protein coupled neurotransmitter receptors.2 The predicted structure of VIPR includes two cysteine residues which are conserved in this receptor family. These are represented at positions 117 and 196 of the VIPR2 and positions 106 and 184 of the hamster beta-adrenergic receptor (BAR).3 Selective replacement of either of these cysteine residues4 in BAR alters the ligand binding properties of the receptor, and a disulfide bond between these residues on adjacent extracellular loops has been implicated in the maintenance of the conformational and functional integrity of the BAR ligand binding site.3,4 The purpose of this work was to examine the ability of lymphocytes to recognize and respond to an analogue of VIP in which cysteine was substituted for serine in the second position of the neuropeptide.", 
    "editor": [
      {
        "familyName": "Mestecky", 
        "givenName": "Jiri", 
        "type": "Person"
      }, 
      {
        "familyName": "Russell", 
        "givenName": "Michael W.", 
        "type": "Person"
      }, 
      {
        "familyName": "Jackson", 
        "givenName": "Susan", 
        "type": "Person"
      }, 
      {
        "familyName": "Michalek", 
        "givenName": "Suzanne M.", 
        "type": "Person"
      }, 
      {
        "familyName": "Tlaskalov\u00e1-Hogenov\u00e1", 
        "givenName": "Helena", 
        "type": "Person"
      }, 
      {
        "familyName": "\u0160terzl", 
        "givenName": "Jaroslav", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4615-1941-6_116", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4613-5796-4", 
        "978-1-4615-1941-6"
      ], 
      "name": "Advances in Mucosal Immunology", 
      "type": "Book"
    }, 
    "keywords": [
      "vasoactive intestinal peptide", 
      "beta-adrenergic receptors", 
      "VIP receptors", 
      "intestinal peptide", 
      "analogs of VIP", 
      "potent immunoregulatory properties", 
      "ability of lymphocytes", 
      "amino acid neuropeptide", 
      "hamster beta-adrenergic receptor", 
      "Nalm-6 cells", 
      "immunoregulatory properties", 
      "neurotransmitter receptors", 
      "murine lymphocytes", 
      "receptors", 
      "receptor family", 
      "G proteins", 
      "lymphocytes", 
      "functional integrity", 
      "neuropeptides", 
      "extracellular loop", 
      "peptides", 
      "cysteine residues", 
      "position 106", 
      "VIPR2", 
      "polypeptide chain", 
      "position 117", 
      "disulfide bonds", 
      "cells", 
      "alters", 
      "residues", 
      "replacement", 
      "analogues", 
      "second position", 
      "maintenance", 
      "serine", 
      "selective replacement", 
      "family", 
      "cysteine", 
      "purpose", 
      "ability", 
      "integrity", 
      "sites", 
      "ligands", 
      "interaction", 
      "loop", 
      "chain", 
      "position", 
      "structure", 
      "properties", 
      "bonds", 
      "work"
    ], 
    "name": "Interaction of a Sulfhydryl Analogue of Vasoactive Intestinal Peptide (VIP) with Murine Lymphocytes", 
    "pagination": "553-558", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013788219"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4615-1941-6_116"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8525988"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4615-1941-6_116", 
      "https://app.dimensions.ai/details/publication/pub.1013788219"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_261.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4615-1941-6_116"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1941-6_116'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1941-6_116'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1941-6_116'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-1941-6_116'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      22 PREDICATES      93 URIs      86 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4615-1941-6_116 schema:about N09361d47ea6b40638fce8084fabbe21b
2 N24e8d3907ded4a308a414841755c3612
3 N38c6e5d640a0444aa0d5663c3490cf54
4 N4b27536528664b6c8c56bfb16ecaafb8
5 N534ca71fcb65495ea2b1972a9c3d6a66
6 N57192262c9af4826b8f25853de002faf
7 N5aa03400165242978e8285a6d580d7bb
8 N6867415fa1ce417b8bd21325825e44ba
9 N70f2f394e9434cbc8061b8008d557786
10 N761e4136343c480ebead1a54a5490914
11 N84695e3cd76346b69f7d879553296dbd
12 N93782c2f4ae84c7cbb28ce95dbc2788b
13 N9b93572e28ce478cbe46e7eb8015b3a4
14 Na8f772b2f2e14cb5bda74b4fe648b112
15 Nae2056d594884a9f9159e68c204c7367
16 Ne7489af471ce4a29a5ec8be956cf92d5
17 anzsrc-for:11
18 anzsrc-for:1115
19 schema:author N74eeb16cfb504fe5bafe0fcaf9f80b2e
20 schema:datePublished 1995
21 schema:datePublishedReg 1995-01-01
22 schema:description Vasoactive intestinal peptide (VIP) is a 28 amino acid neuropeptide with potent immunoregulatory properties.1 The cDN A of the VIP receptor (VIPR) of NALM-6 cells predicts a heptahelical polypeptide chain homologous to other G-protein coupled neurotransmitter receptors.2 The predicted structure of VIPR includes two cysteine residues which are conserved in this receptor family. These are represented at positions 117 and 196 of the VIPR2 and positions 106 and 184 of the hamster beta-adrenergic receptor (BAR).3 Selective replacement of either of these cysteine residues4 in BAR alters the ligand binding properties of the receptor, and a disulfide bond between these residues on adjacent extracellular loops has been implicated in the maintenance of the conformational and functional integrity of the BAR ligand binding site.3,4 The purpose of this work was to examine the ability of lymphocytes to recognize and respond to an analogue of VIP in which cysteine was substituted for serine in the second position of the neuropeptide.
23 schema:editor Na2d3f2c83ba64a8f942ae26cbab03e55
24 schema:genre chapter
25 schema:isAccessibleForFree false
26 schema:isPartOf N92357eb51787401082df7ad7d24398ee
27 schema:keywords G proteins
28 Nalm-6 cells
29 VIP receptors
30 VIPR2
31 ability
32 ability of lymphocytes
33 alters
34 amino acid neuropeptide
35 analogs of VIP
36 analogues
37 beta-adrenergic receptors
38 bonds
39 cells
40 chain
41 cysteine
42 cysteine residues
43 disulfide bonds
44 extracellular loop
45 family
46 functional integrity
47 hamster beta-adrenergic receptor
48 immunoregulatory properties
49 integrity
50 interaction
51 intestinal peptide
52 ligands
53 loop
54 lymphocytes
55 maintenance
56 murine lymphocytes
57 neuropeptides
58 neurotransmitter receptors
59 peptides
60 polypeptide chain
61 position
62 position 106
63 position 117
64 potent immunoregulatory properties
65 properties
66 purpose
67 receptor family
68 receptors
69 replacement
70 residues
71 second position
72 selective replacement
73 serine
74 sites
75 structure
76 vasoactive intestinal peptide
77 work
78 schema:name Interaction of a Sulfhydryl Analogue of Vasoactive Intestinal Peptide (VIP) with Murine Lymphocytes
79 schema:pagination 553-558
80 schema:productId N17eacb649f0b412985708428e155312b
81 N7742381438354fee8176293573d5b9c2
82 Nd7d11afb7b2c4f95b66fb0a6e1e93c2c
83 schema:publisher N0937cff759b2459ab3fb6766745857b3
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013788219
85 https://doi.org/10.1007/978-1-4615-1941-6_116
86 schema:sdDatePublished 2022-09-02T16:12
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N6f3ff06d9b7d40268c105f2c72441406
89 schema:url https://doi.org/10.1007/978-1-4615-1941-6_116
90 sgo:license sg:explorer/license/
91 sgo:sdDataset chapters
92 rdf:type schema:Chapter
93 N02b7110b50ea4a3ab846f046098e05a5 schema:familyName Jackson
94 schema:givenName Susan
95 rdf:type schema:Person
96 N09361d47ea6b40638fce8084fabbe21b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Vasoactive Intestinal Peptide
98 rdf:type schema:DefinedTerm
99 N0937cff759b2459ab3fb6766745857b3 schema:name Springer Nature
100 rdf:type schema:Organisation
101 N0d96b1205571463e814528a7c2eaed98 rdf:first N4e9cd96d4f644bed9bdb858abde5fbdf
102 rdf:rest Nc95073dc4efb4e63a987e61624f960ad
103 N17eacb649f0b412985708428e155312b schema:name doi
104 schema:value 10.1007/978-1-4615-1941-6_116
105 rdf:type schema:PropertyValue
106 N1aa58fa630cf42afa41c354fb39a5b66 rdf:first Nd4e21d56f41949cfad915a5cd5b2bf80
107 rdf:rest Nb974502e890d41cfa89b86356b184bae
108 N1e72eacaa05346b2b35e5500b5192bcb rdf:first Nb88e7020e17b4adda62fdbf531f2af04
109 rdf:rest N1aa58fa630cf42afa41c354fb39a5b66
110 N24e8d3907ded4a308a414841755c3612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mesentery
112 rdf:type schema:DefinedTerm
113 N38c6e5d640a0444aa0d5663c3490cf54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cell Line
115 rdf:type schema:DefinedTerm
116 N4b27536528664b6c8c56bfb16ecaafb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Mice
118 rdf:type schema:DefinedTerm
119 N4e9cd96d4f644bed9bdb858abde5fbdf schema:familyName Russell
120 schema:givenName Michael W.
121 rdf:type schema:Person
122 N534ca71fcb65495ea2b1972a9c3d6a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Lymphocytes
124 rdf:type schema:DefinedTerm
125 N57192262c9af4826b8f25853de002faf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cyclic AMP
127 rdf:type schema:DefinedTerm
128 N5aa03400165242978e8285a6d580d7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Concanavalin A
130 rdf:type schema:DefinedTerm
131 N675676d9048e4c74becb425edde4d41d schema:familyName Šterzl
132 schema:givenName Jaroslav
133 rdf:type schema:Person
134 N6867415fa1ce417b8bd21325825e44ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mitogens
136 rdf:type schema:DefinedTerm
137 N6f3ff06d9b7d40268c105f2c72441406 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N70f2f394e9434cbc8061b8008d557786 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Receptors, Vasoactive Intestinal Peptide
141 rdf:type schema:DefinedTerm
142 N74eeb16cfb504fe5bafe0fcaf9f80b2e rdf:first sg:person.0577250161.89
143 rdf:rest rdf:nil
144 N761e4136343c480ebead1a54a5490914 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Lymphocyte Activation
146 rdf:type schema:DefinedTerm
147 N7742381438354fee8176293573d5b9c2 schema:name dimensions_id
148 schema:value pub.1013788219
149 rdf:type schema:PropertyValue
150 N84695e3cd76346b69f7d879553296dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mice, Inbred BALB C
152 rdf:type schema:DefinedTerm
153 N92357eb51787401082df7ad7d24398ee schema:isbn 978-1-4613-5796-4
154 978-1-4615-1941-6
155 schema:name Advances in Mucosal Immunology
156 rdf:type schema:Book
157 N93782c2f4ae84c7cbb28ce95dbc2788b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Benzodiazepinones
159 rdf:type schema:DefinedTerm
160 N9b93572e28ce478cbe46e7eb8015b3a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Devazepide
162 rdf:type schema:DefinedTerm
163 Na2d3f2c83ba64a8f942ae26cbab03e55 rdf:first Na5a555a0ffb9492d9f59f38fbcbf7bef
164 rdf:rest N0d96b1205571463e814528a7c2eaed98
165 Na5a555a0ffb9492d9f59f38fbcbf7bef schema:familyName Mestecky
166 schema:givenName Jiri
167 rdf:type schema:Person
168 Na8f772b2f2e14cb5bda74b4fe648b112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name 1-Methyl-3-isobutylxanthine
170 rdf:type schema:DefinedTerm
171 Nae2056d594884a9f9159e68c204c7367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Animals
173 rdf:type schema:DefinedTerm
174 Nb88e7020e17b4adda62fdbf531f2af04 schema:familyName Michalek
175 schema:givenName Suzanne M.
176 rdf:type schema:Person
177 Nb974502e890d41cfa89b86356b184bae rdf:first N675676d9048e4c74becb425edde4d41d
178 rdf:rest rdf:nil
179 Nc95073dc4efb4e63a987e61624f960ad rdf:first N02b7110b50ea4a3ab846f046098e05a5
180 rdf:rest N1e72eacaa05346b2b35e5500b5192bcb
181 Nd4e21d56f41949cfad915a5cd5b2bf80 schema:familyName Tlaskalová-Hogenová
182 schema:givenName Helena
183 rdf:type schema:Person
184 Nd7d11afb7b2c4f95b66fb0a6e1e93c2c schema:name pubmed_id
185 schema:value 8525988
186 rdf:type schema:PropertyValue
187 Ne7489af471ce4a29a5ec8be956cf92d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Lymph Nodes
189 rdf:type schema:DefinedTerm
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
194 schema:name Pharmacology and Pharmaceutical Sciences
195 rdf:type schema:DefinedTerm
196 sg:person.0577250161.89 schema:affiliation grid-institutes:grid.17063.33
197 schema:familyName Ottaway
198 schema:givenName C. A.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577250161.89
200 rdf:type schema:Person
201 grid-institutes:grid.17063.33 schema:alternateName Department of Medicine, University of Toronto, M5S 1A8, Toronto, Ontario, Canada
202 schema:name Department of Medicine, University of Toronto, M5S 1A8, Toronto, Ontario, Canada
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...