The Regulation and Function of p21Ras in T Cell Activation and Growth View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

D. A. Cantrell , M. Izquierdo , J. Nunes , N. Osman , K. Reif , M. Woodrow

ABSTRACT

Interleukin-2 (IL-2) regulates the proliferation and functional differentiation of T lymphocytes, B cells and natural killer (NK) cells [1]. IL-2 is secreted by antigen-activated T lymphocytes, and mediates its effects through interaction with a specific high-affinity receptor (IL-2R). The process of T cell activation and growth is initiated by the interaction of antigen with the T cell antigen receptor (TCR), which triggers the G0-G1 transition of the cell cycle, and the induction of IL-2 secretion and IL-2R expression. It is the subsequent IL-2/IL-2R interaction which ultimately drives G1-S phase progression, T cell growth, clonal expansion and functional differentiation [2, 3]. More... »

PAGES

61-76

References to SciGraph publications

Book

TITLE

Normal and Malignant Hematopoiesis

ISBN

978-1-4613-5789-6
978-1-4615-1927-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1927-0_7

DOI

http://dx.doi.org/10.1007/978-1-4615-1927-0_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036337798


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