Alpha-Synuclein View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2001

AUTHORS

Poul Henning Jensen , Wei Ping Gai

ABSTRACT

α-Synuclein is implicated in the pathogenesis of Parkinson’s disease (PD). First, missense mutations in a-synuclein gene lead to familial autosomal dominant PD1,2. Second, abnormal fibrillar a-synuclein accumulate in Lewy bodies in degenerating nerve cells in PD and Dementia with Lewy bodies3. Third, transgenic expression of human a-synuclein in mice and fruitflies leads to the development of Lewy body-like inclusions and neurodegeneration4,5. The 140 amino acid a-synuclein is normally a presynaptic protein with no recognisable secondary structures6. In PD however, changes occur in its cellular localisation and secondary structure as the Lewy bodies contains a-synuclein filaments that resemble amyloid fibrils’. Accordingly, the a-synuclein filaments resemble the intracellular filaments formed in other neurodegenerative diseases by such as tau protein in Alzheimer’s disease and huntingtin in Huntington’s disease. More... »

PAGES

129-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-1249-3_11

DOI

http://dx.doi.org/10.1007/978-1-4615-1249-3_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028126708

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11403154


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