Glucocorticoid Regulation of Cell Proliferation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

E. Aubrey Thompson

ABSTRACT

Initiation of DNA replication in non-embryonic cells requires passage through an irreversible step in late Gl that has come to be called the restriction point. The restriction point was originally defined as the point in time beyond which inhibitors of protein synthesis could not prevent serum-stimulated cells from initiating DNA synthesis (Pardee, 1974). Prevailing wisdom defines the restriction point as irreversible activation of the cyclin E/Cdk2 complex at the Gl/S interphase. As discussed in previous chapters and in several excellent review articles (Sherr and Roberts, 1999; Ekholm and Reed, 2000; Vidal and Koff, 2000), activation of cyclin E/Cdk2 in late Gl begins with two events: 1) relief of transcriptional repression of the cyclin E promoter due to Cdk4-dependent phosphorylation of Rb-1, and the resulting dissociation of chromatin remodeling complexes; and 2) sequestration of Cip/Kip type Cdk2 inhibitors, which occurs as a result of accumulation of cyclin D/Cdk4/p27 and/or cyclin D/Cdk4/p21 complexes. Cdk4-dependent induction of cyclin E transcription and sequestration of the Cdk2 inhibitors Cipl and Kipl results in activation of Cdk2, which then promotes degradation of Kip 1 and further relieves Rb-1 dependent repression of the cyclin E and other promoters. More... »

PAGES

137-146

References to SciGraph publications

Book

TITLE

Steroid Hormones and Cell Cycle Regulation

ISBN

978-1-4613-5327-0
978-1-4615-0965-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0965-3_8

DOI

http://dx.doi.org/10.1007/978-1-4615-0965-3_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029616338


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Medical Branch at Galveston", 
          "id": "https://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "University of Texas Medical Branch, 77555-1048, Galveston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "E. Aubrey", 
        "id": "sg:person.012362237257.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012362237257.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1201902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000680860", 
          "https://doi.org/10.1038/sj.onc.1201902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000680860", 
          "https://doi.org/10.1038/sj.onc.1201902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)89005-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m001048200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001782004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.6.3181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003092980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-0760(00)00080-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003634413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.34.20608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003667263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90723-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006212321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01851328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006707392", 
          "https://doi.org/10.1007/bf01851328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.40.23589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006951784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90636-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009780866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/40.1.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010395189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387417a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011555947", 
          "https://doi.org/10.1038/387417a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.3.2066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014240465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/ajrcmb.21.1.3396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015621946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470514320.ch13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017696303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0773.1995.tb00124.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021619184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0773.1995.tb00124.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021619184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1040980203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023525583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00557951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025245641", 
          "https://doi.org/10.1007/bf00557951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00557951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025245641", 
          "https://doi.org/10.1007/bf00557951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00407888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025920159", 
          "https://doi.org/10.1007/bf00407888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00407888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025920159", 
          "https://doi.org/10.1007/bf00407888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0192-0561(87)90001-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027607113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0192-0561(87)90001-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027607113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.17.10696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027894802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.175.5.1235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028742497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(80)90121-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028742692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.4.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028815228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.12.1501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029101666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-571149-4.50025-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029998618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1092050302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030708721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(00)00151-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031505345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(92)90050-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034177323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02405127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038074476", 
          "https://doi.org/10.1007/bf02405127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02405127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038074476", 
          "https://doi.org/10.1007/bf02405127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.28.17320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038235745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041020214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039538789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.71.4.1286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039725094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(00)00092-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040745163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.5.2576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041088808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371257a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045553304", 
          "https://doi.org/10.1038/371257a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(199812)177:3<396::aid-jcp3>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046514529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02617922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046518420", 
          "https://doi.org/10.1007/bf02617922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02617922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046518420", 
          "https://doi.org/10.1007/bf02617922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1978.tb01994.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048328241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.47.31317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049620736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00009964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049693824", 
          "https://doi.org/10.1007/pl00009964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.4.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052430799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/acta.0.0530189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053125041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi990842e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055217836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi990842e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055217836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv-7-3-254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064243450", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064243873", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-112-5-1739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064257176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-78-2-373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064272318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.136.11.7588206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064279799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.7.9.1121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064329607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.9.11.1500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064329829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-1-12-899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.11.5.9923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.13.11.0379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.13.3.0254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.14.5.0461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.898085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064744349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074486425", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079250682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079505104", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080236669", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081447608", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082456551", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082524223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.8.9.8005391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082604880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082783960", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082915368", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083299040", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002", 
    "datePublishedReg": "2002-01-01", 
    "description": "Initiation of DNA replication in non-embryonic cells requires passage through an irreversible step in late Gl that has come to be called the restriction point. The restriction point was originally defined as the point in time beyond which inhibitors of protein synthesis could not prevent serum-stimulated cells from initiating DNA synthesis (Pardee, 1974). Prevailing wisdom defines the restriction point as irreversible activation of the cyclin E/Cdk2 complex at the Gl/S interphase. As discussed in previous chapters and in several excellent review articles (Sherr and Roberts, 1999; Ekholm and Reed, 2000; Vidal and Koff, 2000), activation of cyclin E/Cdk2 in late Gl begins with two events: 1) relief of transcriptional repression of the cyclin E promoter due to Cdk4-dependent phosphorylation of Rb-1, and the resulting dissociation of chromatin remodeling complexes; and 2) sequestration of Cip/Kip type Cdk2 inhibitors, which occurs as a result of accumulation of cyclin D/Cdk4/p27 and/or cyclin D/Cdk4/p21 complexes. Cdk4-dependent induction of cyclin E transcription and sequestration of the Cdk2 inhibitors Cipl and Kipl results in activation of Cdk2, which then promotes degradation of Kip 1 and further relieves Rb-1 dependent repression of the cyclin E and other promoters.", 
    "editor": [
      {
        "familyName": "Burnstein", 
        "givenName": "Kerry L.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4615-0965-3_8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4613-5327-0", 
        "978-1-4615-0965-3"
      ], 
      "name": "Steroid Hormones and Cell Cycle Regulation", 
      "type": "Book"
    }, 
    "name": "Glucocorticoid Regulation of Cell Proliferation", 
    "pagination": "137-146", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029616338"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4615-0965-3_8"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8d164394c78eec5163d687ef720b13642f72ee7f936195048952a1802b1b24b9"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4615-0965-3_8", 
      "https://app.dimensions.ai/details/publication/pub.1029616338"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T09:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46738_00000001.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-1-4615-0965-3_8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0965-3_8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0965-3_8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0965-3_8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0965-3_8'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      23 PREDICATES      96 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4615-0965-3_8 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N7378473fe3984339a9f01b22982d79b7
4 schema:citation sg:pub.10.1007/bf00407888
5 sg:pub.10.1007/bf00557951
6 sg:pub.10.1007/bf01851328
7 sg:pub.10.1007/bf02405127
8 sg:pub.10.1007/bf02617922
9 sg:pub.10.1007/pl00009964
10 sg:pub.10.1038/371257a0
11 sg:pub.10.1038/387417a0
12 sg:pub.10.1038/sj.onc.1201902
13 https://app.dimensions.ai/details/publication/pub.1064243450
14 https://app.dimensions.ai/details/publication/pub.1064243873
15 https://app.dimensions.ai/details/publication/pub.1074486425
16 https://app.dimensions.ai/details/publication/pub.1079250682
17 https://app.dimensions.ai/details/publication/pub.1079505104
18 https://app.dimensions.ai/details/publication/pub.1080236669
19 https://app.dimensions.ai/details/publication/pub.1081447608
20 https://app.dimensions.ai/details/publication/pub.1082456551
21 https://app.dimensions.ai/details/publication/pub.1082524223
22 https://app.dimensions.ai/details/publication/pub.1082783960
23 https://app.dimensions.ai/details/publication/pub.1082915368
24 https://app.dimensions.ai/details/publication/pub.1083299040
25 https://doi.org/10.1002/(sici)1097-4652(199812)177:3<396::aid-jcp3>3.0.co;2-k
26 https://doi.org/10.1002/9780470514320.ch13
27 https://doi.org/10.1002/ar.1092050302
28 https://doi.org/10.1002/jcp.1040980203
29 https://doi.org/10.1002/jcp.1041020214
30 https://doi.org/10.1016/0014-4827(92)90050-i
31 https://doi.org/10.1016/0092-8674(93)90636-5
32 https://doi.org/10.1016/0092-8674(93)90723-4
33 https://doi.org/10.1016/0192-0561(87)90001-4
34 https://doi.org/10.1016/0303-7207(80)90121-5
35 https://doi.org/10.1016/b978-0-12-571149-4.50025-8
36 https://doi.org/10.1016/s0378-1119(00)00092-5
37 https://doi.org/10.1016/s0955-0674(00)00151-4
38 https://doi.org/10.1016/s0960-0760(00)00080-7
39 https://doi.org/10.1016/s0968-0004(00)89005-2
40 https://doi.org/10.1021/bi990842e
41 https://doi.org/10.1073/pnas.71.4.1286
42 https://doi.org/10.1074/jbc.270.40.23589
43 https://doi.org/10.1074/jbc.271.34.20608
44 https://doi.org/10.1074/jbc.272.28.17320
45 https://doi.org/10.1074/jbc.273.17.10696
46 https://doi.org/10.1074/jbc.273.4.1998
47 https://doi.org/10.1074/jbc.273.4.2008
48 https://doi.org/10.1074/jbc.273.47.31317
49 https://doi.org/10.1074/jbc.m001048200
50 https://doi.org/10.1084/jem.175.5.1235
51 https://doi.org/10.1093/rheumatology/40.1.74
52 https://doi.org/10.1096/fasebj.8.9.8005391
53 https://doi.org/10.1101/gad.13.12.1501
54 https://doi.org/10.1111/j.1365-2133.1978.tb01994.x
55 https://doi.org/10.1111/j.1600-0773.1995.tb00124.x
56 https://doi.org/10.1128/mcb.14.3.2066
57 https://doi.org/10.1128/mcb.17.5.2576
58 https://doi.org/10.1128/mcb.17.6.3181
59 https://doi.org/10.1165/ajrcmb.21.1.3396
60 https://doi.org/10.1210/edrv-7-3-254
61 https://doi.org/10.1210/endo-112-5-1739
62 https://doi.org/10.1210/endo-78-2-373
63 https://doi.org/10.1210/endo.136.11.7588206
64 https://doi.org/10.1210/me.7.9.1121
65 https://doi.org/10.1210/me.9.11.1500
66 https://doi.org/10.1210/mend-1-12-899
67 https://doi.org/10.1210/mend.11.5.9923
68 https://doi.org/10.1210/mend.13.11.0379
69 https://doi.org/10.1210/mend.13.3.0254
70 https://doi.org/10.1210/mend.14.5.0461
71 https://doi.org/10.1289/ehp.898085
72 https://doi.org/10.1530/acta.0.0530189
73 schema:datePublished 2002
74 schema:datePublishedReg 2002-01-01
75 schema:description Initiation of DNA replication in non-embryonic cells requires passage through an irreversible step in late Gl that has come to be called the restriction point. The restriction point was originally defined as the point in time beyond which inhibitors of protein synthesis could not prevent serum-stimulated cells from initiating DNA synthesis (Pardee, 1974). Prevailing wisdom defines the restriction point as irreversible activation of the cyclin E/Cdk2 complex at the Gl/S interphase. As discussed in previous chapters and in several excellent review articles (Sherr and Roberts, 1999; Ekholm and Reed, 2000; Vidal and Koff, 2000), activation of cyclin E/Cdk2 in late Gl begins with two events: 1) relief of transcriptional repression of the cyclin E promoter due to Cdk4-dependent phosphorylation of Rb-1, and the resulting dissociation of chromatin remodeling complexes; and 2) sequestration of Cip/Kip type Cdk2 inhibitors, which occurs as a result of accumulation of cyclin D/Cdk4/p27 and/or cyclin D/Cdk4/p21 complexes. Cdk4-dependent induction of cyclin E transcription and sequestration of the Cdk2 inhibitors Cipl and Kipl results in activation of Cdk2, which then promotes degradation of Kip 1 and further relieves Rb-1 dependent repression of the cyclin E and other promoters.
76 schema:editor N483fa4e459bf4402943fa225bf035447
77 schema:genre chapter
78 schema:inLanguage en
79 schema:isAccessibleForFree false
80 schema:isPartOf N234ce3ac544548f6be00fafcf6de99ea
81 schema:name Glucocorticoid Regulation of Cell Proliferation
82 schema:pagination 137-146
83 schema:productId N5250ebb3470d40ae8d73f4c23f82a538
84 Nb537dfff3fe34814867499dbc63dc70c
85 Nc6087669750843f7b8526eb39b270330
86 schema:publisher N2a29393d298943c9a93710fc28241165
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029616338
88 https://doi.org/10.1007/978-1-4615-0965-3_8
89 schema:sdDatePublished 2019-04-16T09:02
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N46f8f6e27aa24355b74f8fdf37e77abb
92 schema:url https://link.springer.com/10.1007%2F978-1-4615-0965-3_8
93 sgo:license sg:explorer/license/
94 sgo:sdDataset chapters
95 rdf:type schema:Chapter
96 N234ce3ac544548f6be00fafcf6de99ea schema:isbn 978-1-4613-5327-0
97 978-1-4615-0965-3
98 schema:name Steroid Hormones and Cell Cycle Regulation
99 rdf:type schema:Book
100 N2a29393d298943c9a93710fc28241165 schema:location Boston, MA
101 schema:name Springer US
102 rdf:type schema:Organisation
103 N3af95ec6009a4626af2c6bc9da76581d schema:familyName Burnstein
104 schema:givenName Kerry L.
105 rdf:type schema:Person
106 N46f8f6e27aa24355b74f8fdf37e77abb schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N483fa4e459bf4402943fa225bf035447 rdf:first N3af95ec6009a4626af2c6bc9da76581d
109 rdf:rest rdf:nil
110 N5250ebb3470d40ae8d73f4c23f82a538 schema:name doi
111 schema:value 10.1007/978-1-4615-0965-3_8
112 rdf:type schema:PropertyValue
113 N7378473fe3984339a9f01b22982d79b7 rdf:first sg:person.012362237257.28
114 rdf:rest rdf:nil
115 Nb537dfff3fe34814867499dbc63dc70c schema:name readcube_id
116 schema:value 8d164394c78eec5163d687ef720b13642f72ee7f936195048952a1802b1b24b9
117 rdf:type schema:PropertyValue
118 Nc6087669750843f7b8526eb39b270330 schema:name dimensions_id
119 schema:value pub.1029616338
120 rdf:type schema:PropertyValue
121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biological Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biochemistry and Cell Biology
126 rdf:type schema:DefinedTerm
127 sg:person.012362237257.28 schema:affiliation https://www.grid.ac/institutes/grid.176731.5
128 schema:familyName Thompson
129 schema:givenName E. Aubrey
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012362237257.28
131 rdf:type schema:Person
132 sg:pub.10.1007/bf00407888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025920159
133 https://doi.org/10.1007/bf00407888
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/bf00557951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025245641
136 https://doi.org/10.1007/bf00557951
137 rdf:type schema:CreativeWork
138 sg:pub.10.1007/bf01851328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006707392
139 https://doi.org/10.1007/bf01851328
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/bf02405127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038074476
142 https://doi.org/10.1007/bf02405127
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/bf02617922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046518420
145 https://doi.org/10.1007/bf02617922
146 rdf:type schema:CreativeWork
147 sg:pub.10.1007/pl00009964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049693824
148 https://doi.org/10.1007/pl00009964
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/371257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553304
151 https://doi.org/10.1038/371257a0
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/387417a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011555947
154 https://doi.org/10.1038/387417a0
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/sj.onc.1201902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000680860
157 https://doi.org/10.1038/sj.onc.1201902
158 rdf:type schema:CreativeWork
159 https://app.dimensions.ai/details/publication/pub.1064243450 schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1064243873 schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1074486425 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1079250682 schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1079505104 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1080236669 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1081447608 schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1082456551 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1082524223 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1082783960 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1082915368 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1083299040 schema:CreativeWork
171 https://doi.org/10.1002/(sici)1097-4652(199812)177:3<396::aid-jcp3>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1046514529
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/9780470514320.ch13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017696303
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/ar.1092050302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030708721
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/jcp.1040980203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023525583
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/jcp.1041020214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039538789
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0014-4827(92)90050-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1034177323
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0092-8674(93)90636-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009780866
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0092-8674(93)90723-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006212321
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0192-0561(87)90001-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027607113
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0303-7207(80)90121-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028742692
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/b978-0-12-571149-4.50025-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029998618
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0378-1119(00)00092-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040745163
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0955-0674(00)00151-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031505345
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0960-0760(00)00080-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003634413
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0968-0004(00)89005-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616450
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1021/bi990842e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055217836
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1073/pnas.71.4.1286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039725094
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1074/jbc.270.40.23589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006951784
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1074/jbc.271.34.20608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003667263
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1074/jbc.272.28.17320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038235745
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1074/jbc.273.17.10696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027894802
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1074/jbc.273.4.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052430799
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1074/jbc.273.4.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028815228
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1074/jbc.273.47.31317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049620736
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1074/jbc.m001048200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001782004
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1084/jem.175.5.1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028742497
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/rheumatology/40.1.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010395189
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1096/fasebj.8.9.8005391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082604880
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1101/gad.13.12.1501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029101666
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1365-2133.1978.tb01994.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048328241
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/j.1600-0773.1995.tb00124.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021619184
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1128/mcb.14.3.2066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014240465
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1128/mcb.17.5.2576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041088808
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1128/mcb.17.6.3181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003092980
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1165/ajrcmb.21.1.3396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015621946
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1210/edrv-7-3-254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238324
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1210/endo-112-5-1739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064257176
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1210/endo-78-2-373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064272318
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1210/endo.136.11.7588206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064279799
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1210/me.7.9.1121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064329607
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1210/me.9.11.1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064329829
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1210/mend-1-12-899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330017
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1210/mend.11.5.9923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331456
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1210/mend.13.11.0379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331745
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1210/mend.13.3.0254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331791
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1210/mend.14.5.0461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331989
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1289/ehp.898085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064744349
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1530/acta.0.0530189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053125041
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.176731.5 schema:alternateName The University of Texas Medical Branch at Galveston
268 schema:name University of Texas Medical Branch, 77555-1048, Galveston, TX, USA
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...