Apoptosis: The Eyes Have It View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

Bennett D. Elzey , Thomas A. Ferguson

ABSTRACT

Inflammatory immune responses are necessary for host protection against environmental pathogens. Critical to a successful immune response is the clonal expansion of specific lymphocytes. However, after infection, homeostasis must be returned to the immune system to prevent the development of tissue damage that could lead to autoimmunity. CD95-CD95L-mediated apoptosis is a central component of this process.1 Indeed, mice deficient in functional CD95 or CD95L (lprandgld, respectively) suffer from massive accumulation of lymphocytes and loss of self-tolerance. 2 In addition to reducing lymphocyte numbers, induction of apoptosis is associated with regulation or prevention of inflammatory responses to normal cellular antigens.3 More... »

PAGES

815-820

References to SciGraph publications

  • 2000-10. Corpse clearance defines the meaning of cell death in NATURE
  • 1873-10. Die Entwickelung der in fremden Grund versetzten lebenden Gewebe in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4615-0717-8_115

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    http://dx.doi.org/10.1007/978-1-4615-0717-8_115

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12613997


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