Expression of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor 1α in the Myocardium View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Toshiyuki Takahashi , Yasuyuki Sugishita , Tatsuya Shimizu , Atsushi Yao , Kazumasa Harada , Ryozo Nagai

ABSTRACT

Expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α), a transcription factor involved in the VEGF induction, was examined in the myocardium. In the 10-day-old chick embryonic hearts and ventricular myocytes, the mRNA species encoding VEGF and HIF-1α were abundantly expressed even at the basal conditions. The steady-state levels of the VEGF mRNA were regulated by various protein kinases. In the cultured neonatal rat ventricular myocytes, VEGF expression was upregulated by lipopolysaccharide. These data suggest that VEGF and HIF-1α expressed in cardiac myocytes may play significant roles in cardiovascular development. Furthermore, the cardiac myocyte-derived VEGF may also contribute to the pathogenesis of systemic inflammatory response syndrome, including myocardial interstitial edema. More... »

PAGES

439-447

Book

TITLE

Signal Transduction and Cardiac Hypertrophy

ISBN

978-1-4613-5032-3
978-1-4615-0347-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0347-7_32

DOI

http://dx.doi.org/10.1007/978-1-4615-0347-7_32

DIMENSIONS

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