Expression of Indoleamine 2,3-Dioxygenase In Carcinoma of Human Endometrium And Uterine Cervix View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Peter Sedlmayr , Michaela Semlitsch , Osamu Takikawa , Gottfried Dohr , Girmai Gebrut , Eva Karpf , Olaf Reich , Tao Tang , Reinhold Wintersteiger

ABSTRACT

Expression of indoleamine 2,3-dioxygenase (IDO) in epithelium of the endometrium and the cervix is not restricted to normal but also present in carcinomatous tissue. The enzyme was found in the majority of cases studied, pioneer cells at the invasion front of the tumors being especially strongly reactive in immunohistology. In addition, also cells in the peritumoral infiltrate of the stroma expressed IDO. Taken together, these findings together with previous data on the immunosuppressive impact of tryptophan depletion suggest IDO-induced suppression of antitumoral immune response in both adenocarcinoma and squamous cell carcinoma of endometrium and cervix. On the other hand, IDO as also known to inhibit tumor cell proliferation by tryptophan depletion. More... »

PAGES

91-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0135-0_10

DOI

http://dx.doi.org/10.1007/978-1-4615-0135-0_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019674237

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15206720


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