Driving the Cell Cycle to Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Marcos Malumbres , Sarah L. Hunt , Rocío Sotillo , Javier Martín , Jun Odajima , Alberto Martín , Pierre Dubus , Sagrario Ortega , Mariano Barbacid

ABSTRACT

Cell cycle progression requires the co-ordinated activation of several kinases, some of which are activated upon the binding of a cyclin subunit. At least four of these so-called cyclin-dependent kinases, namely Cdk4, Cdk6, Cdk2 and Cdkl, have specific roles at particular stages of the cell cycle, including passage through the various cell cycle transitions and the response to specific checkpoints. Not surprisingly, most human tumors carry mutations that deregulate at least one of these kinases. To analyze their specific role in vivo, we are generating strains of gene-targeted mice carrying either activated or defective alleles of these Cdks. As an example, Cdk4 expression appears to be expendable in most cell types since mice lacking Cdk4 are viable. Yet, Cdk4 mutant mice are smaller in size and infertile (only partial infertility in males). In addition, Cdk4 defective mice develop insulin dependent diabetes early in life. However, the importance of these Cdks in tumor cell cycles is underscored by the phenotype of knock in mice where the normal Cdk4 gene has been replaced by a Cdk4 R24C (insensitive to INK inhibitors) mutant. These animals develop a wide spectrum of spontaneous tumors and are highly susceptible to specific carcinogenic treatments. These models are being used now to understand how deregulation of these Cdks leads to cancer development and will be a valuable tool to design and validate new therapeutic strategies against tumour development. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0081-0_1

DOI

http://dx.doi.org/10.1007/978-1-4615-0081-0_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050970506

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12908544


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDC2 Protein Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDC2-CDC28 Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase 6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Mutant Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malumbres", 
        "givenName": "Marcos", 
        "id": "sg:person.0716321250.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunt", 
        "givenName": "Sarah L.", 
        "id": "sg:person.01167364066.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167364066.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotillo", 
        "givenName": "Roc\u00edo", 
        "id": "sg:person.0647742247.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647742247.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00edn", 
        "givenName": "Javier", 
        "id": "sg:person.01303612466.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303612466.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odajima", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00edn", 
        "givenName": "Alberto", 
        "id": "sg:person.01044151077.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044151077.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bourdeaux, Bourdeaux, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "University of Bourdeaux, Bourdeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubus", 
        "givenName": "Pierre", 
        "id": "sg:person.01105017171.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105017171.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ortega", 
        "givenName": "Sagrario", 
        "id": "sg:person.0725461355.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725461355.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbacid", 
        "givenName": "Mariano", 
        "id": "sg:person.0101555544.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101555544.84"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2003", 
    "datePublishedReg": "2003-01-01", 
    "description": "Cell cycle progression requires the co-ordinated activation of several kinases, some of which are activated upon the binding of a cyclin subunit. At least four of these so-called cyclin-dependent kinases, namely Cdk4, Cdk6, Cdk2 and Cdkl, have specific roles at particular stages of the cell cycle, including passage through the various cell cycle transitions and the response to specific checkpoints. Not surprisingly, most human tumors carry mutations that deregulate at least one of these kinases. To analyze their specific role in vivo, we are generating strains of gene-targeted mice carrying either activated or defective alleles of these Cdks. As an example, Cdk4 expression appears to be expendable in most cell types since mice lacking Cdk4 are viable. Yet, Cdk4 mutant mice are smaller in size and infertile (only partial infertility in males). In addition, Cdk4 defective mice develop insulin dependent diabetes early in life. However, the importance of these Cdks in tumor cell cycles is underscored by the phenotype of knock in mice where the normal Cdk4 gene has been replaced by a Cdk4 R24C (insensitive to INK inhibitors) mutant. These animals develop a wide spectrum of spontaneous tumors and are highly susceptible to specific carcinogenic treatments. These models are being used now to understand how deregulation of these Cdks leads to cancer development and will be a valuable tool to design and validate new therapeutic strategies against tumour development.", 
    "editor": [
      {
        "familyName": "Llombart-Bosch", 
        "givenName": "Antonio", 
        "type": "Person"
      }, 
      {
        "familyName": "Felipo", 
        "givenName": "Vicente", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4615-0081-0_1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4613-4914-3", 
        "978-1-4615-0081-0"
      ], 
      "name": "New Trends in Cancer for the 21stCentury", 
      "type": "Book"
    }, 
    "keywords": [
      "cell cycle", 
      "cyclin-dependent kinases", 
      "co-ordinated activation", 
      "most cell types", 
      "cell cycle progression", 
      "cell cycle transition", 
      "specific role", 
      "cyclin subunit", 
      "specific checkpoints", 
      "cycle progression", 
      "gene-targeted mice", 
      "cycle transition", 
      "CDK", 
      "most human tumors", 
      "cell types", 
      "kinase", 
      "defective alleles", 
      "tumor cell cycle", 
      "cancer development", 
      "tumor development", 
      "CDK4", 
      "defective mice", 
      "new therapeutic strategies", 
      "mutant mice", 
      "human tumors", 
      "CDK4 expression", 
      "insulin dependent diabetes", 
      "particular stage", 
      "CDK4 gene", 
      "dependent diabetes", 
      "genes", 
      "cdkl", 
      "checkpoint", 
      "therapeutic strategies", 
      "subunits", 
      "CDK2", 
      "carcinogenic treatment", 
      "valuable tool", 
      "spontaneous tumors", 
      "CDK6", 
      "mice", 
      "mutations", 
      "phenotype", 
      "alleles", 
      "deregulation", 
      "knock", 
      "cycle", 
      "role", 
      "wide spectrum", 
      "expression", 
      "binding", 
      "tumors", 
      "activation", 
      "vivo", 
      "strains", 
      "development", 
      "animals", 
      "diabetes", 
      "cancer", 
      "progression", 
      "infertile", 
      "stage", 
      "treatment", 
      "response", 
      "importance", 
      "addition", 
      "passage", 
      "types", 
      "size", 
      "life", 
      "strategies", 
      "tool", 
      "transition", 
      "example", 
      "model", 
      "spectra", 
      "Cdk4 mutant mice", 
      "Cdk4 defective mice", 
      "phenotype of knock", 
      "normal Cdk4 gene", 
      "specific carcinogenic treatments"
    ], 
    "name": "Driving the Cell Cycle to Cancer", 
    "pagination": "1-11", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050970506"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4615-0081-0_1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12908544"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4615-0081-0_1", 
      "https://app.dimensions.ai/details/publication/pub.1050970506"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2021-11-01T18:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/chapter/chapter_216.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4615-0081-0_1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0081-0_1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0081-0_1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0081-0_1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4615-0081-0_1'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      23 PREDICATES      128 URIs      121 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4615-0081-0_1 schema:about N166cee7e73f74bf5be1aaa2cd060d3d5
2 N251a5305f2ae433d89e52a87e3faca8e
3 N2b05c66e2e7c4ce6859b3f818c6ce261
4 N41e6e02cf3be493b9592d6400f479c50
5 N45e72b71caca45e5bb78c0af886aeba8
6 N547013cac4fb43d7abf5982be8b911d0
7 N61cd7ff7d0464d3c847786fee3a6e839
8 N78114bf4fab44a9092260521063461fd
9 N810171aa9a1c4f93acdc6c966532145a
10 N833b6203d2344acfb7b7c06a7fdd14ec
11 N96d694b8214f41c0b199dcf995f7de7c
12 Nb167de9222954f57b4d6370bb1c08376
13 Nb80825c68f0349a4a35d5c5c9cabdf4c
14 Nbb8b1adbf3c44431a718b8a5e214f931
15 Nbe4170b71f6a4d6785cc15d77c7dfbd7
16 Nc1b83eb8f77f464280327b1f9974969e
17 Nce6d1bf5a33f45279e958725465e1fe2
18 Nd8def22e34f7405c8a66d65643a746d6
19 Ndc42d5ff62b34becb23b8aae7d31de0a
20 Necd776fb573d46e388a25649beb42688
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N025532e1626f47888cd62b57495a409b
24 schema:datePublished 2003
25 schema:datePublishedReg 2003-01-01
26 schema:description Cell cycle progression requires the co-ordinated activation of several kinases, some of which are activated upon the binding of a cyclin subunit. At least four of these so-called cyclin-dependent kinases, namely Cdk4, Cdk6, Cdk2 and Cdkl, have specific roles at particular stages of the cell cycle, including passage through the various cell cycle transitions and the response to specific checkpoints. Not surprisingly, most human tumors carry mutations that deregulate at least one of these kinases. To analyze their specific role in vivo, we are generating strains of gene-targeted mice carrying either activated or defective alleles of these Cdks. As an example, Cdk4 expression appears to be expendable in most cell types since mice lacking Cdk4 are viable. Yet, Cdk4 mutant mice are smaller in size and infertile (only partial infertility in males). In addition, Cdk4 defective mice develop insulin dependent diabetes early in life. However, the importance of these Cdks in tumor cell cycles is underscored by the phenotype of knock in mice where the normal Cdk4 gene has been replaced by a Cdk4 R24C (insensitive to INK inhibitors) mutant. These animals develop a wide spectrum of spontaneous tumors and are highly susceptible to specific carcinogenic treatments. These models are being used now to understand how deregulation of these Cdks leads to cancer development and will be a valuable tool to design and validate new therapeutic strategies against tumour development.
27 schema:editor N11eb514a8fd444cfbc0a5c7912b0b3fe
28 schema:genre chapter
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf Ne9878edee4c5402a8c8cd8980c78f6d7
32 schema:keywords CDK
33 CDK2
34 CDK4
35 CDK4 expression
36 CDK4 gene
37 CDK6
38 Cdk4 defective mice
39 Cdk4 mutant mice
40 activation
41 addition
42 alleles
43 animals
44 binding
45 cancer
46 cancer development
47 carcinogenic treatment
48 cdkl
49 cell cycle
50 cell cycle progression
51 cell cycle transition
52 cell types
53 checkpoint
54 co-ordinated activation
55 cycle
56 cycle progression
57 cycle transition
58 cyclin subunit
59 cyclin-dependent kinases
60 defective alleles
61 defective mice
62 dependent diabetes
63 deregulation
64 development
65 diabetes
66 example
67 expression
68 gene-targeted mice
69 genes
70 human tumors
71 importance
72 infertile
73 insulin dependent diabetes
74 kinase
75 knock
76 life
77 mice
78 model
79 most cell types
80 most human tumors
81 mutant mice
82 mutations
83 new therapeutic strategies
84 normal Cdk4 gene
85 particular stage
86 passage
87 phenotype
88 phenotype of knock
89 progression
90 response
91 role
92 size
93 specific carcinogenic treatments
94 specific checkpoints
95 specific role
96 spectra
97 spontaneous tumors
98 stage
99 strains
100 strategies
101 subunits
102 therapeutic strategies
103 tool
104 transition
105 treatment
106 tumor cell cycle
107 tumor development
108 tumors
109 types
110 valuable tool
111 vivo
112 wide spectrum
113 schema:name Driving the Cell Cycle to Cancer
114 schema:pagination 1-11
115 schema:productId N17993be074854a57831482b9ab69c295
116 N3af7fc27699a4a7f8e4ce553012e6816
117 N3c7fe4a7dde84385a73b3d0045cc352c
118 schema:publisher Na03b63c10f3845e2adb10e4540b862c6
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050970506
120 https://doi.org/10.1007/978-1-4615-0081-0_1
121 schema:sdDatePublished 2021-11-01T18:50
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N8b5db8bed0cf42afba4d0a98bf8875cc
124 schema:url https://doi.org/10.1007/978-1-4615-0081-0_1
125 sgo:license sg:explorer/license/
126 sgo:sdDataset chapters
127 rdf:type schema:Chapter
128 N025532e1626f47888cd62b57495a409b rdf:first sg:person.0716321250.19
129 rdf:rest N044b5e5a5a1443c28464ade9322b06b2
130 N044b5e5a5a1443c28464ade9322b06b2 rdf:first sg:person.01167364066.41
131 rdf:rest Ncceb222a12604635b9a25956b2e239bb
132 N11eb514a8fd444cfbc0a5c7912b0b3fe rdf:first Nfdb75055ff9746f2a643243fcfd2e1c1
133 rdf:rest N34f15176ced244dc8308d64c10c6c39c
134 N166cee7e73f74bf5be1aaa2cd060d3d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Time Factors
136 rdf:type schema:DefinedTerm
137 N17993be074854a57831482b9ab69c295 schema:name doi
138 schema:value 10.1007/978-1-4615-0081-0_1
139 rdf:type schema:PropertyValue
140 N251a5305f2ae433d89e52a87e3faca8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Models, Biological
142 rdf:type schema:DefinedTerm
143 N2b05c66e2e7c4ce6859b3f818c6ce261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation, Neoplastic
145 rdf:type schema:DefinedTerm
146 N34f15176ced244dc8308d64c10c6c39c rdf:first N53bbb94e97e64fd7946f6006404a750e
147 rdf:rest rdf:nil
148 N3af7fc27699a4a7f8e4ce553012e6816 schema:name pubmed_id
149 schema:value 12908544
150 rdf:type schema:PropertyValue
151 N3c7fe4a7dde84385a73b3d0045cc352c schema:name dimensions_id
152 schema:value pub.1050970506
153 rdf:type schema:PropertyValue
154 N41e6e02cf3be493b9592d6400f479c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Proto-Oncogene Proteins
156 rdf:type schema:DefinedTerm
157 N45e72b71caca45e5bb78c0af886aeba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice, Mutant Strains
159 rdf:type schema:DefinedTerm
160 N53bbb94e97e64fd7946f6006404a750e schema:familyName Felipo
161 schema:givenName Vicente
162 rdf:type schema:Person
163 N541d58506df64483a7d3f6db71adc66c rdf:first Nacd76357c0f648859605770896501a08
164 rdf:rest Ne174c2e124344bc8adcb0714dd5bec50
165 N547013cac4fb43d7abf5982be8b911d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mice
167 rdf:type schema:DefinedTerm
168 N5f11a1e0e1b64c21b8a93b13a786a9a0 rdf:first sg:person.0725461355.91
169 rdf:rest N8e011a06707c4ab7acec0cf843f1eb25
170 N61cd7ff7d0464d3c847786fee3a6e839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cyclin-Dependent Kinase 2
172 rdf:type schema:DefinedTerm
173 N78114bf4fab44a9092260521063461fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Animals
175 rdf:type schema:DefinedTerm
176 N810171aa9a1c4f93acdc6c966532145a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name CDC2 Protein Kinase
178 rdf:type schema:DefinedTerm
179 N833b6203d2344acfb7b7c06a7fdd14ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 N8b5db8bed0cf42afba4d0a98bf8875cc schema:name Springer Nature - SN SciGraph project
183 rdf:type schema:Organization
184 N8cec9366479d4329849a940e2d7f2ca0 rdf:first sg:person.01105017171.35
185 rdf:rest N5f11a1e0e1b64c21b8a93b13a786a9a0
186 N8e011a06707c4ab7acec0cf843f1eb25 rdf:first sg:person.0101555544.84
187 rdf:rest rdf:nil
188 N96d694b8214f41c0b199dcf995f7de7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Phosphorylation
190 rdf:type schema:DefinedTerm
191 N978992d9fd024c5884c021134a8b1d76 rdf:first sg:person.01303612466.07
192 rdf:rest N541d58506df64483a7d3f6db71adc66c
193 Na03b63c10f3845e2adb10e4540b862c6 schema:name Springer Nature
194 rdf:type schema:Organisation
195 Nacd76357c0f648859605770896501a08 schema:affiliation grid-institutes:grid.7719.8
196 schema:familyName Odajima
197 schema:givenName Jun
198 rdf:type schema:Person
199 Nb167de9222954f57b4d6370bb1c08376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Cyclin-Dependent Kinase 6
201 rdf:type schema:DefinedTerm
202 Nb80825c68f0349a4a35d5c5c9cabdf4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Female
204 rdf:type schema:DefinedTerm
205 Nbb8b1adbf3c44431a718b8a5e214f931 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Cell Cycle
207 rdf:type schema:DefinedTerm
208 Nbe4170b71f6a4d6785cc15d77c7dfbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Male
210 rdf:type schema:DefinedTerm
211 Nc1b83eb8f77f464280327b1f9974969e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Cyclin-Dependent Kinase 4
213 rdf:type schema:DefinedTerm
214 Ncceb222a12604635b9a25956b2e239bb rdf:first sg:person.0647742247.84
215 rdf:rest N978992d9fd024c5884c021134a8b1d76
216 Nce6d1bf5a33f45279e958725465e1fe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Diabetes Mellitus, Type 1
218 rdf:type schema:DefinedTerm
219 Nd8def22e34f7405c8a66d65643a746d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name CDC2-CDC28 Kinases
221 rdf:type schema:DefinedTerm
222 Ndc42d5ff62b34becb23b8aae7d31de0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Neoplasms
224 rdf:type schema:DefinedTerm
225 Ne174c2e124344bc8adcb0714dd5bec50 rdf:first sg:person.01044151077.77
226 rdf:rest N8cec9366479d4329849a940e2d7f2ca0
227 Ne9878edee4c5402a8c8cd8980c78f6d7 schema:isbn 978-1-4613-4914-3
228 978-1-4615-0081-0
229 schema:name New Trends in Cancer for the 21stCentury
230 rdf:type schema:Book
231 Necd776fb573d46e388a25649beb42688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Cyclin-Dependent Kinases
233 rdf:type schema:DefinedTerm
234 Nfdb75055ff9746f2a643243fcfd2e1c1 schema:familyName Llombart-Bosch
235 schema:givenName Antonio
236 rdf:type schema:Person
237 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
238 schema:name Medical and Health Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
241 schema:name Oncology and Carcinogenesis
242 rdf:type schema:DefinedTerm
243 sg:person.0101555544.84 schema:affiliation grid-institutes:grid.7719.8
244 schema:familyName Barbacid
245 schema:givenName Mariano
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101555544.84
247 rdf:type schema:Person
248 sg:person.01044151077.77 schema:affiliation grid-institutes:grid.7719.8
249 schema:familyName Martín
250 schema:givenName Alberto
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044151077.77
252 rdf:type schema:Person
253 sg:person.01105017171.35 schema:affiliation grid-institutes:None
254 schema:familyName Dubus
255 schema:givenName Pierre
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105017171.35
257 rdf:type schema:Person
258 sg:person.01167364066.41 schema:affiliation grid-institutes:grid.7719.8
259 schema:familyName Hunt
260 schema:givenName Sarah L.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167364066.41
262 rdf:type schema:Person
263 sg:person.01303612466.07 schema:affiliation grid-institutes:grid.7719.8
264 schema:familyName Martín
265 schema:givenName Javier
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303612466.07
267 rdf:type schema:Person
268 sg:person.0647742247.84 schema:affiliation grid-institutes:grid.7719.8
269 schema:familyName Sotillo
270 schema:givenName Rocío
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647742247.84
272 rdf:type schema:Person
273 sg:person.0716321250.19 schema:affiliation grid-institutes:grid.7719.8
274 schema:familyName Malumbres
275 schema:givenName Marcos
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19
277 rdf:type schema:Person
278 sg:person.0725461355.91 schema:affiliation grid-institutes:grid.7719.8
279 schema:familyName Ortega
280 schema:givenName Sagrario
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725461355.91
282 rdf:type schema:Person
283 grid-institutes:None schema:alternateName University of Bourdeaux, Bourdeaux, France
284 schema:name University of Bourdeaux, Bourdeaux, France
285 rdf:type schema:Organization
286 grid-institutes:grid.7719.8 schema:alternateName Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
287 schema:name Molecular Oncology Progamme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...