Effects of the Contrast Medium Iopromide on Renal Hemodynamics and Oxygen Tension in the Diabetic Rat Kidney View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Fredrik Palm , Per-Ola Carlsson , Angelica Fasching , Olof Hellberg , Anders Nygren , Peter Hansell , Per Liss

ABSTRACT

We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats. RESULTS: In normoglycemic rats, CM injection induced a transient decrease followed by an increase in renal cortical blood flow (CBF), whereas CBF increased directly in the diabetic animals. Renal outer medullary blood flow (OMBF) increased in controls, while it decreased in the diabetic animals following CM injection. In control rats a marked initial decrease in OM pO2 following injection of CM was observed. In animals diabetic for 4 weeks only a slight decrease was seen, whereas in 9-week diabetic animals a persistent increase was recorded. CONCLUSIONS: An altered oxygen tension and hemodynamic response to CM was found in diabetic rats. If these disturbances may contribute to the development of renal dysfunction by CM in the diabetic rat kidney remains to be elucidated. More... »

PAGES

653-659

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0075-9_65

DOI

http://dx.doi.org/10.1007/978-1-4615-0075-9_65

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003439958

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14562763


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