A Vaccine for Nontypable Haemophilus influenzae View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Allan W. Cripps , Jennelle M. Kyd

ABSTRACT

Nontypable H. influenzae (NTHI) is a common commensal of the upper respiratory tract residing in both the nasopharynx and the posterior oropharynx. It is one of the leading causative bacterial pathogens of otitis media (OM) in children and serious urogenital, neonatal and mother-infant infections. It is also the cause of significant morbidity in patients with pulmonary diseases such as cystic fibrosis and chronic obstructive pulmonary disease. NTHI colonizes the respiratory tract through adherence to the mucous and epithelial cells. It has several bacterial surface components that have the capacity to facilitate adherence and interactions between the bacterium and epithelial cells, setting the stage for the cycle of inflammation. Whole killed cell or bacterial extracts have been investigated in human trials providing results that demonstrate the potential for a vaccine to protect against infection. Several lead candidate antigens have been proposed based on studies in animal models but have yet to be formulated for human trials. The composition of a vaccine requires that the antigens be conserved among strains, immunogenic and protective against infection and that the delivery of the vaccine results in the relevant immune response, probably a balance of specific cellular and humoral responses. More... »

PAGES

244-259

Book

TITLE

New Bacterial Vaccines

ISBN

978-1-4613-4902-0
978-1-4615-0053-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-0053-7_16

DOI

http://dx.doi.org/10.1007/978-1-4615-0053-7_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003851032


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