ROUNDABOUT Receptors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013-10-17

AUTHORS

Athéna R. Ypsilanti , Alain Chedotal

ABSTRACT

Roundabout receptors (Robo) and their Slit ligands were discovered in the 1990s and found to be key players in axon guidance. Slit was initially described as an extracellular matrix protein that was expressed by midline glia in Drosophila. A few years later, it was shown that, in vertebrates and invertebrates, Slits acted as chemorepellents for axons crossing the midline. Robo proteins were originally discovered in Drosophila in a mutant screen for genes involved in the regulation of midline crossing. This ligand–receptor pair has since been implicated in a variety of other neuronal and non-neuronal processes ranging from cell migration to angiogenesis, tumourigenesis and even organogenesis of tissues such as kidneys, lungs and breasts. More... »

PAGES

133-164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-8090-7_7

DOI

http://dx.doi.org/10.1007/978-1-4614-8090-7_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002174391

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25300136


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