Biophysics of Titin in Cardiac Health and Disease View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2013

AUTHORS

Brian R. Anderson , Henk L. Granzier

ABSTRACT

Titin is a gigantic multifunctional filamentous protein that spans from the Z-disk to the M-band region of the cardiac sarcomere. The elastic I-band region of titin generates passive force during sarcomere stretch that plays important roles in maintaining the structural organization of the sarcomere and that contributes greatly to diastolic stiffness. Recent work has shown that to match hemodynamic demands the mechanical properties of titin can be finely tuned through differential expression of titin isoforms and phosphorylation of titin’s spring-like elements. Titin may also play a role in mechanically sensing sarcomere length changes due to its placement in the sarcomere and extensible, force-bearing I-band region. The precise ways in which titin behaves as a mechanosensor is not well established, but rapid progress is being made in our understanding of the various proteins involved in signaling pathways that interact with titin. Recent work also revealed mutations in the titin gene (TTN) as a major source of familial cardiomyopathies, including mutations in titin’s spring region linked to arrhythmogenic right ventricular dysplasia and mutations in titin’s A-band region responsible for ~30 % of dilated cardiomyopathy (DCM) cases. This chapter discusses the mechanical properties of titin and the role titin plays in cardiac health and disease. More... »

PAGES

201-223

Book

TITLE

Biophysics of the Failing Heart

ISBN

978-1-4614-7677-1
978-1-4614-7678-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-7678-8_10

DOI

http://dx.doi.org/10.1007/978-1-4614-7678-8_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028881693


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Department of Physics, University of Arizona, Tucson, AZ\u00a085724, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anderson", 
        "givenName": "Brian R.", 
        "id": "sg:person.01347723546.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347723546.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Department of Physiology, Molecular Cardiovascular Research Program, Sarver Heart Center, University of Arizona, Tucson, AZ\u00a085724, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Granzier", 
        "givenName": "Henk L.", 
        "id": "sg:person.01366174473.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366174473.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm.2693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000224289", 
          "https://doi.org/10.1038/nm.2693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.86.11.1114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000634576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200108089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000723250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10974-005-9039-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000737252", 
          "https://doi.org/10.1007/s10974-005-9039-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10974-005-9039-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000737252", 
          "https://doi.org/10.1007/s10974-005-9039-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.26.14418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001018320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002336909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003750379", 
          "https://doi.org/10.1038/nature04343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003750379", 
          "https://doi.org/10.1038/nature04343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003750379", 
          "https://doi.org/10.1038/nature04343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r800037200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005199250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0608543104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005315167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90192-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005734618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005459605964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007184392", 
          "https://doi.org/10.1023/a:1005459605964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0134(20010501)43:2<145::aid-prot1026>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007270388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2009.05.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007585047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)01226-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007885071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10974-006-9090-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008163814", 
          "https://doi.org/10.1007/s10974-006-9090-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddn160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008362798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008662267", 
          "https://doi.org/10.1038/nature00938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008662267", 
          "https://doi.org/10.1038/nature00938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.200409177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008688214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1977.sp011911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009100619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1752-8062.2010.00198.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009121550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1752-8062.2010.00198.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009121550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.148288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009419524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.148288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009419524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.107.106153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011950789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2011.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012103765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2011.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012103765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.104.052423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013314528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10974-005-9017-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013439582", 
          "https://doi.org/10.1007/s10974-005-9017-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10974-005-9017-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013439582", 
          "https://doi.org/10.1007/s10974-005-9017-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.106.645499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014522666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m809743200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015831603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.84.11.1339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016022704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000029804.61510.02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017427602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2004.03.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017575171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017602659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017602659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000115522.52554.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018355005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000115522.52554.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018355005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hh2301.100981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018381711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.372839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020251387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.401372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020429085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.7.3694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021126447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.8.4750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021469507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1110463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022976989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci34472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023004087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(98)77556-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023030474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(00)76555-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023102939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000021115.24712.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023417804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.105.5.2217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023612032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025569154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025569154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000124301.48193.e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025655195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000124301.48193.e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025655195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.110.005405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025722528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000135591.37759.af", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025797205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(94)80728-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025827933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1994.1312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027372492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200356200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027688200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.198465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028329948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.198465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028329948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.2002.4458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028566449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2004.08.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028628569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2011.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028708084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2011.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028708084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-2126(01)00591-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029472723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(99)77149-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029749158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1110186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031030718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0805034105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031154946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308789200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031524476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2006.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/753675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035210910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2009.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035489010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.1998.3993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035813557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-2126(01)00170-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036267345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036921040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036921040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2011.06.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036998759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2011.06.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036998759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/347037a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037388616", 
          "https://doi.org/10.1038/347037a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037603869", 
          "https://doi.org/10.1038/81964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211723200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038369855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.63.1.391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039063973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2009.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039622503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.87.3.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040134131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(01)75876-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040958289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(95)80278-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040968146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.33.1.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042429494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2009.05.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042633155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-2126(96)00036-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043967560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/47083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044096909", 
          "https://doi.org/10.1038/47083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/47083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044096909", 
          "https://doi.org/10.1038/47083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-7644com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044152118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044339514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044339514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044846175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.2002.4468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045403467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.86.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046141990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymgme.2005.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047720219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2011.01.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047854034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.106.5.1563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049635874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2005.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050242313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2005.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050242313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.76.8.3698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050879735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physchem.56.092503.141240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051065961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.143.4.1013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052270008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052416232", 
          "https://doi.org/10.1038/27603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052416232", 
          "https://doi.org/10.1038/27603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.184408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052655352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.184408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052655352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052865564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000029803.93022.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053209653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2009.12.4192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053371034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(03)00328-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054578521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(99)00268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ehj.2003.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054732331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00181a604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055164154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0022792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055166106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0022792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055166106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5234.293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5346.2075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062559038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.347575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062616182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.91.1.161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063335858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a131291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074253019"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013", 
    "datePublishedReg": "2013-01-01", 
    "description": "Titin is a gigantic multifunctional filamentous protein that spans from the Z-disk to the M-band region of the cardiac sarcomere. The elastic I-band region of titin generates passive force during sarcomere stretch that plays important roles in maintaining the structural organization of the sarcomere and that contributes greatly to diastolic stiffness. Recent work has shown that to match hemodynamic demands the mechanical properties of titin can be finely tuned through differential expression of titin isoforms and phosphorylation of titin\u2019s spring-like elements. Titin may also play a role in mechanically sensing sarcomere length changes due to its placement in the sarcomere and extensible, force-bearing I-band region. The precise ways in which titin behaves as a mechanosensor is not well established, but rapid progress is being made in our understanding of the various proteins involved in signaling pathways that interact with titin. Recent work also revealed mutations in the titin gene (TTN) as a major source of familial cardiomyopathies, including mutations in titin\u2019s spring region linked to arrhythmogenic right ventricular dysplasia and mutations in titin\u2019s A-band region responsible for ~30 % of dilated cardiomyopathy (DCM) cases. This chapter discusses the mechanical properties of titin and the role titin plays in cardiac health and disease.", 
    "editor": [
      {
        "familyName": "Solaro", 
        "givenName": "R. John", 
        "type": "Person"
      }, 
      {
        "familyName": "Tardiff", 
        "givenName": "Jil C.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4614-7678-8_10", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2536939", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2684151", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": {
      "isbn": [
        "978-1-4614-7677-1", 
        "978-1-4614-7678-8"
      ], 
      "name": "Biophysics of the Failing Heart", 
      "type": "Book"
    }, 
    "name": "Biophysics of Titin in Cardiac Health and Disease", 
    "pagination": "201-223", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4614-7678-8_10"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "899604f1969a62217540d984c59f5df6a1cd45959899934c65ee95516e32a6fa"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028881693"
        ]
      }
    ], 
    "publisher": {
      "location": "New York, NY", 
      "name": "Springer New York", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4614-7678-8_10", 
      "https://app.dimensions.ai/details/publication/pub.1028881693"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T16:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000049.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4614-7678-8_10"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-7678-8_10'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-7678-8_10'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-7678-8_10'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-7678-8_10'


 

This table displays all metadata directly associated to this object as RDF triples.

408 TRIPLES      23 PREDICATES      132 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4614-7678-8_10 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N7f0df60d229a47e4b0f384e96cc581f6
4 schema:citation sg:pub.10.1007/s10974-005-9017-6
5 sg:pub.10.1007/s10974-005-9039-0
6 sg:pub.10.1007/s10974-006-9090-5
7 sg:pub.10.1023/a:1005459605964
8 sg:pub.10.1038/27603
9 sg:pub.10.1038/347037a0
10 sg:pub.10.1038/47083
11 sg:pub.10.1038/81964
12 sg:pub.10.1038/nature00938
13 sg:pub.10.1038/nature04343
14 sg:pub.10.1038/nm.2693
15 https://doi.org/10.1002/1097-0134(20010501)43:2<145::aid-prot1026>3.0.co;2-b
16 https://doi.org/10.1006/jmbi.1994.1312
17 https://doi.org/10.1006/jsbi.1998.3993
18 https://doi.org/10.1006/jsbi.2002.4458
19 https://doi.org/10.1006/jsbi.2002.4468
20 https://doi.org/10.1016/0092-8674(94)90192-9
21 https://doi.org/10.1016/j.bpj.2009.05.037
22 https://doi.org/10.1016/j.bpj.2009.12.4192
23 https://doi.org/10.1016/j.bpj.2011.01.059
24 https://doi.org/10.1016/j.bpj.2011.06.054
25 https://doi.org/10.1016/j.ehj.2003.10.015
26 https://doi.org/10.1016/j.jacc.2004.08.058
27 https://doi.org/10.1016/j.jacc.2009.05.038
28 https://doi.org/10.1016/j.jmb.2003.09.012
29 https://doi.org/10.1016/j.jmb.2004.03.071
30 https://doi.org/10.1016/j.jmb.2005.05.021
31 https://doi.org/10.1016/j.jsb.2006.02.017
32 https://doi.org/10.1016/j.pharmthera.2009.05.002
33 https://doi.org/10.1016/j.str.2005.12.005
34 https://doi.org/10.1016/j.yjmcc.2009.12.006
35 https://doi.org/10.1016/j.yjmcc.2011.01.005
36 https://doi.org/10.1016/j.yjmcc.2011.06.006
37 https://doi.org/10.1016/j.ymgme.2005.10.008
38 https://doi.org/10.1016/s0006-3495(00)76555-6
39 https://doi.org/10.1016/s0006-3495(01)75876-6
40 https://doi.org/10.1016/s0006-3495(94)80728-3
41 https://doi.org/10.1016/s0006-3495(95)80278-x
42 https://doi.org/10.1016/s0006-3495(98)77556-3
43 https://doi.org/10.1016/s0006-3495(99)77149-3
44 https://doi.org/10.1016/s0008-6363(03)00328-6
45 https://doi.org/10.1016/s0008-6363(99)00268-0
46 https://doi.org/10.1016/s0092-8674(02)01226-6
47 https://doi.org/10.1016/s0969-2126(01)00170-8
48 https://doi.org/10.1016/s0969-2126(01)00591-3
49 https://doi.org/10.1016/s0969-2126(96)00036-6
50 https://doi.org/10.1021/bi00181a604
51 https://doi.org/10.1021/bi0022792
52 https://doi.org/10.1038/sj.emboj.7601952
53 https://doi.org/10.1042/cs20070430
54 https://doi.org/10.1056/nejmoa1110186
55 https://doi.org/10.1073/pnas.0608543104
56 https://doi.org/10.1073/pnas.0805034105
57 https://doi.org/10.1073/pnas.76.8.3698
58 https://doi.org/10.1073/pnas.94.26.14418
59 https://doi.org/10.1073/pnas.96.7.3694
60 https://doi.org/10.1074/jbc.m112.372839
61 https://doi.org/10.1074/jbc.m112.401372
62 https://doi.org/10.1074/jbc.m200356200
63 https://doi.org/10.1074/jbc.m211723200
64 https://doi.org/10.1074/jbc.m308789200
65 https://doi.org/10.1074/jbc.m809743200
66 https://doi.org/10.1074/jbc.r800037200
67 https://doi.org/10.1083/jcb.105.5.2217
68 https://doi.org/10.1083/jcb.106.5.1563
69 https://doi.org/10.1083/jcb.143.4.1013
70 https://doi.org/10.1083/jcb.200108089
71 https://doi.org/10.1085/jgp.200409177
72 https://doi.org/10.1093/hmg/ddn160
73 https://doi.org/10.1093/oxfordjournals.jbchem.a131291
74 https://doi.org/10.1096/fj.06-7644com
75 https://doi.org/10.1111/j.1752-8062.2010.00198.x
76 https://doi.org/10.1113/jphysiol.1977.sp011911
77 https://doi.org/10.1126/science.1110463
78 https://doi.org/10.1126/science.270.5234.293
79 https://doi.org/10.1126/science.278.5346.2075
80 https://doi.org/10.1126/science.347575
81 https://doi.org/10.1128/mcb.17.8.4750
82 https://doi.org/10.1146/annurev.physchem.56.092503.141240
83 https://doi.org/10.1146/annurev.physiol.63.1.391
84 https://doi.org/10.1155/2010/753675
85 https://doi.org/10.1161/01.cir.0000029803.93022.93
86 https://doi.org/10.1161/01.cir.0000029804.61510.02
87 https://doi.org/10.1161/01.cir.0000135591.37759.af
88 https://doi.org/10.1161/01.cir.91.1.161
89 https://doi.org/10.1161/01.hyp.33.1.60
90 https://doi.org/10.1161/01.res.0000021115.24712.99
91 https://doi.org/10.1161/01.res.0000115522.52554.86
92 https://doi.org/10.1161/01.res.0000124301.48193.e1
93 https://doi.org/10.1161/01.res.84.11.1339
94 https://doi.org/10.1161/01.res.86.1.59
95 https://doi.org/10.1161/01.res.86.11.1114
96 https://doi.org/10.1161/01.res.87.3.235
97 https://doi.org/10.1161/circresaha.107.148288
98 https://doi.org/10.1161/circresaha.108.184408
99 https://doi.org/10.1161/circresaha.109.198465
100 https://doi.org/10.1161/circresaha.109.200964
101 https://doi.org/10.1161/circulationaha.106.645499
102 https://doi.org/10.1161/circulationaha.110.005405
103 https://doi.org/10.1161/hh2301.100981
104 https://doi.org/10.1172/jci34472
105 https://doi.org/10.1242/jcs.00181
106 https://doi.org/10.1242/jcs.01501
107 https://doi.org/10.1529/biophysj.104.052423
108 https://doi.org/10.1529/biophysj.107.106153
109 schema:datePublished 2013
110 schema:datePublishedReg 2013-01-01
111 schema:description Titin is a gigantic multifunctional filamentous protein that spans from the Z-disk to the M-band region of the cardiac sarcomere. The elastic I-band region of titin generates passive force during sarcomere stretch that plays important roles in maintaining the structural organization of the sarcomere and that contributes greatly to diastolic stiffness. Recent work has shown that to match hemodynamic demands the mechanical properties of titin can be finely tuned through differential expression of titin isoforms and phosphorylation of titin’s spring-like elements. Titin may also play a role in mechanically sensing sarcomere length changes due to its placement in the sarcomere and extensible, force-bearing I-band region. The precise ways in which titin behaves as a mechanosensor is not well established, but rapid progress is being made in our understanding of the various proteins involved in signaling pathways that interact with titin. Recent work also revealed mutations in the titin gene (TTN) as a major source of familial cardiomyopathies, including mutations in titin’s spring region linked to arrhythmogenic right ventricular dysplasia and mutations in titin’s A-band region responsible for ~30 % of dilated cardiomyopathy (DCM) cases. This chapter discusses the mechanical properties of titin and the role titin plays in cardiac health and disease.
112 schema:editor Nd0be07fd1c0244d5813a61c3c25148e3
113 schema:genre chapter
114 schema:inLanguage en
115 schema:isAccessibleForFree true
116 schema:isPartOf Nb81e784b191646e99dbd2bec4a917610
117 schema:name Biophysics of Titin in Cardiac Health and Disease
118 schema:pagination 201-223
119 schema:productId N2b45d83cff124ac3af029d8e036eb0a5
120 N3e1d2e725a4a4a35b04885efa83470d9
121 N5bed928790284024b4f900df964a830b
122 schema:publisher N33ba860475484ca79cf715a4da880971
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028881693
124 https://doi.org/10.1007/978-1-4614-7678-8_10
125 schema:sdDatePublished 2019-04-15T16:04
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher Nfa5e855e1a5146e3a463bd9ec50287a1
128 schema:url http://link.springer.com/10.1007/978-1-4614-7678-8_10
129 sgo:license sg:explorer/license/
130 sgo:sdDataset chapters
131 rdf:type schema:Chapter
132 N1da036db30334d97b4a5226d72b4962b rdf:first Naa4285bdc644433d982c24a9f6b10c7c
133 rdf:rest rdf:nil
134 N29b1b031b83949019862264666533a14 rdf:first sg:person.01366174473.47
135 rdf:rest rdf:nil
136 N2b45d83cff124ac3af029d8e036eb0a5 schema:name dimensions_id
137 schema:value pub.1028881693
138 rdf:type schema:PropertyValue
139 N33ba860475484ca79cf715a4da880971 schema:location New York, NY
140 schema:name Springer New York
141 rdf:type schema:Organisation
142 N3e1d2e725a4a4a35b04885efa83470d9 schema:name doi
143 schema:value 10.1007/978-1-4614-7678-8_10
144 rdf:type schema:PropertyValue
145 N419996dbedf24841ba3e5faf5a38ea56 schema:familyName Solaro
146 schema:givenName R. John
147 rdf:type schema:Person
148 N5bed928790284024b4f900df964a830b schema:name readcube_id
149 schema:value 899604f1969a62217540d984c59f5df6a1cd45959899934c65ee95516e32a6fa
150 rdf:type schema:PropertyValue
151 N7f0df60d229a47e4b0f384e96cc581f6 rdf:first sg:person.01347723546.52
152 rdf:rest N29b1b031b83949019862264666533a14
153 Naa4285bdc644433d982c24a9f6b10c7c schema:familyName Tardiff
154 schema:givenName Jil C.
155 rdf:type schema:Person
156 Nb81e784b191646e99dbd2bec4a917610 schema:isbn 978-1-4614-7677-1
157 978-1-4614-7678-8
158 schema:name Biophysics of the Failing Heart
159 rdf:type schema:Book
160 Nd0be07fd1c0244d5813a61c3c25148e3 rdf:first N419996dbedf24841ba3e5faf5a38ea56
161 rdf:rest N1da036db30334d97b4a5226d72b4962b
162 Nfa5e855e1a5146e3a463bd9ec50287a1 schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biological Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biochemistry and Cell Biology
169 rdf:type schema:DefinedTerm
170 sg:grant.2536939 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4614-7678-8_10
171 rdf:type schema:MonetaryGrant
172 sg:grant.2684151 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4614-7678-8_10
173 rdf:type schema:MonetaryGrant
174 sg:person.01347723546.52 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
175 schema:familyName Anderson
176 schema:givenName Brian R.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347723546.52
178 rdf:type schema:Person
179 sg:person.01366174473.47 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
180 schema:familyName Granzier
181 schema:givenName Henk L.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366174473.47
183 rdf:type schema:Person
184 sg:pub.10.1007/s10974-005-9017-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013439582
185 https://doi.org/10.1007/s10974-005-9017-6
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/s10974-005-9039-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000737252
188 https://doi.org/10.1007/s10974-005-9039-0
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s10974-006-9090-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008163814
191 https://doi.org/10.1007/s10974-006-9090-5
192 rdf:type schema:CreativeWork
193 sg:pub.10.1023/a:1005459605964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007184392
194 https://doi.org/10.1023/a:1005459605964
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/27603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052416232
197 https://doi.org/10.1038/27603
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/347037a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037388616
200 https://doi.org/10.1038/347037a0
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/47083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044096909
203 https://doi.org/10.1038/47083
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/81964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037603869
206 https://doi.org/10.1038/81964
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/nature00938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008662267
209 https://doi.org/10.1038/nature00938
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/nature04343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003750379
212 https://doi.org/10.1038/nature04343
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nm.2693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000224289
215 https://doi.org/10.1038/nm.2693
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/1097-0134(20010501)43:2<145::aid-prot1026>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1007270388
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1006/jmbi.1994.1312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027372492
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1006/jsbi.1998.3993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035813557
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1006/jsbi.2002.4458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028566449
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1006/jsbi.2002.4468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045403467
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0092-8674(94)90192-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005734618
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.bpj.2009.05.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042633155
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.bpj.2009.12.4192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053371034
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.bpj.2011.01.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047854034
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.bpj.2011.06.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036998759
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.ehj.2003.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054732331
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.jacc.2004.08.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028628569
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.jacc.2009.05.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007585047
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.jmb.2003.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025569154
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.jmb.2004.03.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017575171
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.jmb.2005.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036921040
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.jsb.2006.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032374188
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.pharmthera.2009.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035489010
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.str.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050242313
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.yjmcc.2009.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039622503
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.yjmcc.2011.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012103765
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.yjmcc.2011.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028708084
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ymgme.2005.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047720219
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0006-3495(00)76555-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023102939
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0006-3495(01)75876-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040958289
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0006-3495(94)80728-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025827933
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0006-3495(95)80278-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040968146
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0006-3495(98)77556-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030474
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0006-3495(99)77149-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029749158
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0008-6363(03)00328-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578521
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0008-6363(99)00268-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580571
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0092-8674(02)01226-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007885071
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0969-2126(01)00170-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036267345
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0969-2126(01)00591-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029472723
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0969-2126(96)00036-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043967560
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1021/bi00181a604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055164154
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1021/bi0022792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055166106
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1038/sj.emboj.7601952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002336909
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1042/cs20070430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044339514
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1056/nejmoa1110186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031030718
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.0608543104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005315167
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.0805034105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031154946
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.76.8.3698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050879735
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.94.26.14418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001018320
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.96.7.3694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021126447
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m112.372839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020251387
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1074/jbc.m112.401372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020429085
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.m200356200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027688200
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.m211723200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038369855
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.m308789200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031524476
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m809743200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015831603
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.r800037200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005199250
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1083/jcb.105.5.2217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023612032
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1083/jcb.106.5.1563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049635874
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1083/jcb.143.4.1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052270008
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1083/jcb.200108089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000723250
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1085/jgp.200409177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008688214
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/hmg/ddn160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008362798
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/oxfordjournals.jbchem.a131291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074253019
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1096/fj.06-7644com schema:sameAs https://app.dimensions.ai/details/publication/pub.1044152118
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1752-8062.2010.00198.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009121550
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1113/jphysiol.1977.sp011911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009100619
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1126/science.1110463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022976989
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1126/science.270.5234.293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551443
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1126/science.278.5346.2075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559038
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1126/science.347575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062616182
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1128/mcb.17.8.4750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021469507
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1146/annurev.physchem.56.092503.141240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051065961
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1146/annurev.physiol.63.1.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039063973
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1155/2010/753675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035210910
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1161/01.cir.0000029803.93022.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053209653
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1161/01.cir.0000029804.61510.02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017427602
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1161/01.cir.0000135591.37759.af schema:sameAs https://app.dimensions.ai/details/publication/pub.1025797205
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1161/01.cir.91.1.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063335858
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1161/01.hyp.33.1.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042429494
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1161/01.res.0000021115.24712.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023417804
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1161/01.res.0000115522.52554.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018355005
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1161/01.res.0000124301.48193.e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025655195
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1161/01.res.84.11.1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016022704
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1161/01.res.86.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046141990
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1161/01.res.86.11.1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000634576
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1161/01.res.87.3.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134131
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1161/circresaha.107.148288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009419524
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1161/circresaha.108.184408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052655352
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1161/circresaha.109.198465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028329948
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1161/circresaha.109.200964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017602659
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1161/circulationaha.106.645499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014522666
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1161/circulationaha.110.005405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025722528
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1161/hh2301.100981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018381711
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1172/jci34472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023004087
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1242/jcs.00181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044846175
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1242/jcs.01501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052865564
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1529/biophysj.104.052423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013314528
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1529/biophysj.107.106153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011950789
404 rdf:type schema:CreativeWork
405 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
406 schema:name Department of Physics, University of Arizona, Tucson, AZ 85724, USA
407 Department of Physiology, Molecular Cardiovascular Research Program, Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USA
408 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...