Side Effects of Systemic Therapy and Their Clinical Management View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Suthee Rapisuwon , Geoffrey T. Gibney

ABSTRACT

Understanding when to interrupt or permanently discontinue systemic therapy in patients with advanced melanoma is dependent on the class of therapy, type of adverse event, and severity. Criteria for resuming therapy following adverse events differs among drug classes. While patients can be re-challenged with reduced doses of BRAF and MEK inhibitors after improvement or resolution of toxicities, grade 2 or higher immune related adverse events (irAEs) associated with immune checkpoint inhibitor therapy usually requires drug interruption or discontinuation and upfront corticosteroids. This chapter will discuss toxicities of BRAF-targeted therapy, current immune checkpoint inhibitors, and injectable oncolytic viral therapy as well as toxicity management guidelines. The toxicities associated with targeted and immune checkpoint inhibitor therapies in patients with advanced melanoma present unique challenges to providers and patients. More... »

PAGES

1-17

References to SciGraph publications

Book

TITLE

Melanoma

ISBN

978-1-4614-7322-0
978-1-4614-7322-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-7322-0_22-1

DOI

http://dx.doi.org/10.1007/978-1-4614-7322-0_22-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099700163


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