Obesity, Inflammation, and Prostate Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Jorge Blando , Achinto Saha , Kaoru Kiguchi , John DiGiovanni

ABSTRACT

Obesity and the associated metabolic syndrome produce a complex set of alterations both systemically and locally in tissues that support cancer development and progression. In prostate cancer (PCa), the weight of evidence suggests that obesity is primarily associated with more aggressive disease and increased risk of biochemical failure following prostatectomy or radiation treatment. Inflammation processes and inflammation-associated signaling pathways are upregulated in the obese state, and both human and mouse studies support an important role for inflammation in obesity-driven PCa progression. Inflammation signaling pathways along with other signaling pathways (e.g., growth factor signaling pathways) altered in the obese state represent promising targets for both lifestyle and pharmacologic interventions to prevent or control PCa progression. More... »

PAGES

235-256

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  • Book

    TITLE

    Obesity, Inflammation and Cancer

    ISBN

    978-1-4614-6818-9
    978-1-4614-6819-6

    Author Affiliations

    From Grant

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4614-6819-6_10

    DOI

    http://dx.doi.org/10.1007/978-1-4614-6819-6_10

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015134243


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