Evaluation of the Taurine Concentrations in Dog Plasma and Aqueous Humour: A Pilot Study View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013-01-10

AUTHORS

Serge-George Rosolen , Nathalie Neveux , José-Alain Sahel , Serge Picaud , Nicolas Froger

ABSTRACT

In the 70s, the amino acid taurine was found essential for photoreceptor survival. Recently, we found that taurine depletion can also trigger retinal ganglion cell degeneration both in vitro and in vivo. Therefore, evaluation of taurine levels could be a crucial biomarker for different pathologies of retinal ganglion cells such as glaucoma. Because different breeds of dog can develop glaucoma, we performed taurine measurements on plasma and aqueous humour samples from pet dogs. Here, we exposed results from a pilot study on normal selected breed of pet dogs, without any ocular pathology. Samples were collected by veterinarians who belong to the Réseau Européen d’Ophtalmologie Vétérinaire et de Vision Animale. Following measurements by high-performance liquid chromatography (HPLC), the averaged taurine concentration was 162.3 μM in the plasma and 51.8 μM in the aqueous humour. No correlation was observed between these two taurine concentrations, which exhibited a ratio close to 3. Further studies will determine if these taurine concentrations are changed in glaucomatous dogs. More... »

PAGES

145-154

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-6130-2_12

DOI

http://dx.doi.org/10.1007/978-1-4614-6130-2_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050182209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23392931


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