Toll-Like Receptor-Linked Signal Transduction in Angiogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013-03-01

AUTHORS

Karsten Grote , Harald Schütt , Bernhard Schieffer

ABSTRACT

Mammalian Toll-like receptors (TLRs) represent pattern recognition receptors of the immune system and are related to the Toll protein of Drosophila. Pathogen-associated molecular patterns (PAMPs) of microbial and viral origin bind to TLRs and initiate the innate and adaptive immune response. However, TLRs are not solely found on cells of the immune system but also on nonmyeloid cells in various tissues, e.g., on vascular cells. In addition to PAMPs, there is increasing evidence that TLRs also recognize endogenous ligands. Recent studies demonstrate the contribution of distinct TLRs in different inflammatory disorders such as cardiovascular diseases, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Many of these disorders are characterized by enhanced angiogenesis which is mainly trigged by inflammation. However, this inflammation-induced angiogenesis is not only important for pathogen defense during acute infection or chronic inflammatory disorders but as well involved in regenerative processes during wound healing and tissue repair. There is cumulative evidence that TLR activation by exogenous as well as endogenous ligands especially contributes to angiogenic process in this scenario. The present chapter will summarize the current understanding of TLR-linked signal transduction in angiogenesis during inflammatory processes with future prospects for pro- or antiangiogenic therapy. More... »

PAGES

139-157

Book

TITLE

Biochemical Basis and Therapeutic Implications of Angiogenesis

ISBN

978-1-4614-5856-2
978-1-4614-5857-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-5857-9_9

DOI

http://dx.doi.org/10.1007/978-1-4614-5857-9_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026024539


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grote", 
        "givenName": "Karsten", 
        "id": "sg:person.01205175326.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205175326.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fctt", 
        "givenName": "Harald", 
        "id": "sg:person.01166524205.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166524205.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schieffer", 
        "givenName": "Bernhard", 
        "id": "sg:person.01075113266.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2013-03-01", 
    "datePublishedReg": "2013-03-01", 
    "description": "Mammalian Toll-like receptors (TLRs) represent pattern recognition receptors of the immune system and are related to the Toll protein of Drosophila. Pathogen-associated molecular patterns (PAMPs) of microbial and viral origin bind to TLRs and initiate the innate and adaptive immune response. However, TLRs are not solely found on cells of the immune system but also on nonmyeloid cells in various tissues, e.g., on vascular cells. In addition to PAMPs, there is increasing evidence that TLRs also recognize endogenous ligands. Recent studies demonstrate the contribution of distinct TLRs in different inflammatory disorders such as cardiovascular diseases, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Many of these disorders are characterized by enhanced angiogenesis which is mainly trigged by inflammation. However, this inflammation-induced angiogenesis is not only important for pathogen defense during acute infection or chronic inflammatory disorders but as well involved in regenerative processes during wound healing and tissue repair. There is cumulative evidence that TLR activation by exogenous as well as endogenous ligands especially contributes to angiogenic process in this scenario. The present chapter will summarize the current understanding of TLR-linked signal transduction in angiogenesis during inflammatory processes with future prospects for pro- or antiangiogenic therapy.", 
    "editor": [
      {
        "familyName": "Mehta", 
        "givenName": "Jawahar L.", 
        "type": "Person"
      }, 
      {
        "familyName": "Dhalla", 
        "givenName": "Naranjan S.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4614-5857-9_9", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4614-5856-2", 
        "978-1-4614-5857-9"
      ], 
      "name": "Biochemical Basis and Therapeutic Implications of Angiogenesis", 
      "type": "Book"
    }, 
    "keywords": [
      "Toll-like receptors", 
      "pathogen-associated molecular patterns", 
      "inflammatory disorders", 
      "immune system", 
      "endogenous ligand", 
      "distinct Toll-like receptors", 
      "systemic lupus erythematosus", 
      "chronic inflammatory disorders", 
      "different inflammatory disorders", 
      "adaptive immune responses", 
      "mammalian Toll-like receptors", 
      "inflammation-induced angiogenesis", 
      "pattern recognition receptors", 
      "lupus erythematosus", 
      "acute infection", 
      "rheumatoid arthritis", 
      "TLR activation", 
      "inflammatory process", 
      "signal transduction", 
      "cardiovascular disease", 
      "antiangiogenic therapy", 
      "immune response", 
      "recognition receptors", 
      "nonmyeloid cells", 
      "enhanced angiogenesis", 
      "vascular cells", 
      "molecular patterns", 
      "cumulative evidence", 
      "wound healing", 
      "angiogenesis", 
      "receptors", 
      "disorders", 
      "tissue repair", 
      "regenerative processes", 
      "pathogen defense", 
      "Toll protein", 
      "Recent studies", 
      "cells", 
      "current understanding", 
      "erythematosus", 
      "arthritis", 
      "inflammation", 
      "therapy", 
      "cancer", 
      "infection", 
      "transduction", 
      "disease", 
      "evidence", 
      "healing", 
      "tissue", 
      "repair", 
      "activation", 
      "Drosophila", 
      "response", 
      "protein", 
      "binds", 
      "present chapter", 
      "study", 
      "ligands", 
      "defense", 
      "future prospects", 
      "patterns", 
      "addition", 
      "process", 
      "understanding", 
      "system", 
      "chapter", 
      "contribution", 
      "prospects", 
      "scenarios"
    ], 
    "name": "Toll-Like Receptor-Linked Signal Transduction in Angiogenesis", 
    "pagination": "139-157", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026024539"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4614-5857-9_9"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4614-5857-9_9", 
      "https://app.dimensions.ai/details/publication/pub.1026024539"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_202.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4614-5857-9_9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-5857-9_9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-5857-9_9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-5857-9_9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4614-5857-9_9'


 

This table displays all metadata directly associated to this object as RDF triples.

156 TRIPLES      22 PREDICATES      95 URIs      86 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4614-5857-9_9 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 anzsrc-for:11
4 anzsrc-for:1107
5 schema:author N6aa442216c654d6d9d2b6e888e3b1e78
6 schema:datePublished 2013-03-01
7 schema:datePublishedReg 2013-03-01
8 schema:description Mammalian Toll-like receptors (TLRs) represent pattern recognition receptors of the immune system and are related to the Toll protein of Drosophila. Pathogen-associated molecular patterns (PAMPs) of microbial and viral origin bind to TLRs and initiate the innate and adaptive immune response. However, TLRs are not solely found on cells of the immune system but also on nonmyeloid cells in various tissues, e.g., on vascular cells. In addition to PAMPs, there is increasing evidence that TLRs also recognize endogenous ligands. Recent studies demonstrate the contribution of distinct TLRs in different inflammatory disorders such as cardiovascular diseases, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Many of these disorders are characterized by enhanced angiogenesis which is mainly trigged by inflammation. However, this inflammation-induced angiogenesis is not only important for pathogen defense during acute infection or chronic inflammatory disorders but as well involved in regenerative processes during wound healing and tissue repair. There is cumulative evidence that TLR activation by exogenous as well as endogenous ligands especially contributes to angiogenic process in this scenario. The present chapter will summarize the current understanding of TLR-linked signal transduction in angiogenesis during inflammatory processes with future prospects for pro- or antiangiogenic therapy.
9 schema:editor Ne29191c2a0374068bc26dba8549673e9
10 schema:genre chapter
11 schema:isAccessibleForFree false
12 schema:isPartOf Ne00ab1a054264c1aa141416ffd7a32ce
13 schema:keywords Drosophila
14 Recent studies
15 TLR activation
16 Toll protein
17 Toll-like receptors
18 activation
19 acute infection
20 adaptive immune responses
21 addition
22 angiogenesis
23 antiangiogenic therapy
24 arthritis
25 binds
26 cancer
27 cardiovascular disease
28 cells
29 chapter
30 chronic inflammatory disorders
31 contribution
32 cumulative evidence
33 current understanding
34 defense
35 different inflammatory disorders
36 disease
37 disorders
38 distinct Toll-like receptors
39 endogenous ligand
40 enhanced angiogenesis
41 erythematosus
42 evidence
43 future prospects
44 healing
45 immune response
46 immune system
47 infection
48 inflammation
49 inflammation-induced angiogenesis
50 inflammatory disorders
51 inflammatory process
52 ligands
53 lupus erythematosus
54 mammalian Toll-like receptors
55 molecular patterns
56 nonmyeloid cells
57 pathogen defense
58 pathogen-associated molecular patterns
59 pattern recognition receptors
60 patterns
61 present chapter
62 process
63 prospects
64 protein
65 receptors
66 recognition receptors
67 regenerative processes
68 repair
69 response
70 rheumatoid arthritis
71 scenarios
72 signal transduction
73 study
74 system
75 systemic lupus erythematosus
76 therapy
77 tissue
78 tissue repair
79 transduction
80 understanding
81 vascular cells
82 wound healing
83 schema:name Toll-Like Receptor-Linked Signal Transduction in Angiogenesis
84 schema:pagination 139-157
85 schema:productId Na24fd5bbcd2a4e89ba858309acd4a916
86 Ne3ebcaeeace74afbbfc1e8a344931594
87 schema:publisher Nd15102e24b8e4affa85e844adc1fc820
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026024539
89 https://doi.org/10.1007/978-1-4614-5857-9_9
90 schema:sdDatePublished 2022-09-02T16:11
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Ncaf5c246d9ba425690a45bd174685742
93 schema:url https://doi.org/10.1007/978-1-4614-5857-9_9
94 sgo:license sg:explorer/license/
95 sgo:sdDataset chapters
96 rdf:type schema:Chapter
97 N015977a53ea140fca76d73b1373a3aaf rdf:first Neb3ddc79ba0346f6abebc3cdaa2532e4
98 rdf:rest rdf:nil
99 N499e095a20eb4770a077c457dfa07d9a rdf:first sg:person.01166524205.94
100 rdf:rest Na736fc7966f94b1c8b81e0e4b6ef553b
101 N6aa442216c654d6d9d2b6e888e3b1e78 rdf:first sg:person.01205175326.76
102 rdf:rest N499e095a20eb4770a077c457dfa07d9a
103 Na24fd5bbcd2a4e89ba858309acd4a916 schema:name dimensions_id
104 schema:value pub.1026024539
105 rdf:type schema:PropertyValue
106 Na3f92f2aff1a4c3b848ebad5735c0c7c schema:familyName Mehta
107 schema:givenName Jawahar L.
108 rdf:type schema:Person
109 Na736fc7966f94b1c8b81e0e4b6ef553b rdf:first sg:person.01075113266.30
110 rdf:rest rdf:nil
111 Ncaf5c246d9ba425690a45bd174685742 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 Nd15102e24b8e4affa85e844adc1fc820 schema:name Springer Nature
114 rdf:type schema:Organisation
115 Ne00ab1a054264c1aa141416ffd7a32ce schema:isbn 978-1-4614-5856-2
116 978-1-4614-5857-9
117 schema:name Biochemical Basis and Therapeutic Implications of Angiogenesis
118 rdf:type schema:Book
119 Ne29191c2a0374068bc26dba8549673e9 rdf:first Na3f92f2aff1a4c3b848ebad5735c0c7c
120 rdf:rest N015977a53ea140fca76d73b1373a3aaf
121 Ne3ebcaeeace74afbbfc1e8a344931594 schema:name doi
122 schema:value 10.1007/978-1-4614-5857-9_9
123 rdf:type schema:PropertyValue
124 Neb3ddc79ba0346f6abebc3cdaa2532e4 schema:familyName Dhalla
125 schema:givenName Naranjan S.
126 rdf:type schema:Person
127 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biological Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
131 schema:name Biochemistry and Cell Biology
132 rdf:type schema:DefinedTerm
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
137 schema:name Immunology
138 rdf:type schema:DefinedTerm
139 sg:person.01075113266.30 schema:affiliation grid-institutes:grid.10423.34
140 schema:familyName Schieffer
141 schema:givenName Bernhard
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30
143 rdf:type schema:Person
144 sg:person.01166524205.94 schema:affiliation grid-institutes:grid.10423.34
145 schema:familyName Schütt
146 schema:givenName Harald
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166524205.94
148 rdf:type schema:Person
149 sg:person.01205175326.76 schema:affiliation grid-institutes:grid.10423.34
150 schema:familyName Grote
151 schema:givenName Karsten
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205175326.76
153 rdf:type schema:Person
154 grid-institutes:grid.10423.34 schema:alternateName Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany
155 schema:name Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany
156 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...