Engraftment: Homing and Use of Genetic Markers View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Mirjana Pavlovic , Bela Balint

ABSTRACT

Homing refers to the stem cells’ innate ability to travel to the right place in the body—the bone marrow—suited for making blood. The term “engraftment” means that the stem cells have begun their work; they are functioning properly within the marrow by producing various kinds of blood cells. Not only that bone marrow is recruited with fresh pool of concentrated stem cells, but it is also being gradually repopulated by those cells that emerge through differentiation of transplanted stem cells. Experimental evidence suggests that manipulated stem cells may lose some of their homing and engraftment abilities. If this evidence is true for humans as well, a troubling paradox may arise: The very success of an umbilical cord blood transplant could be undermined by the manipulations performed on stem cells—manipulations intended to increase their healing properties, not decrease or eliminate them. Research needs to clarify this. Work of this kind, at the University of Minnesota, is crucial to the success of stem cell expansion [1]. More... »

PAGES

69-70

References to SciGraph publications

Book

TITLE

Stem Cells and Tissue Engineering

ISBN

978-1-4614-5504-2
978-1-4614-5505-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-5505-9_12

DOI

http://dx.doi.org/10.1007/978-1-4614-5505-9_12

DIMENSIONS

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