Kidney Function After In Vivo Gene Silencing of Uncoupling Protein-2 in Streptozotocin-Induced Diabetic Rats View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2013

AUTHORS

Malou Friederich Persson , William J. Welch , Christopher S. Wilcox , Fredrik Palm

ABSTRACT

Kidney uncoupling protein 2 (UCP-2) increases in streptozotocin-induced diabetes, resulting in mitochondria uncoupling, i.e., increased oxygen consumption unrelated to active transport. The present study aimed to investigate the role of UCP-2 for normal and diabetic kidney function utilizing small interference RNA (siRNA) to reduce protein expression. Diabetic animals had increased glomerular filtration rate and kidney oxygen consumption, resulting in decreased oxygen tension and transported sodium per consumed oxygen. UCP-2 protein levels decreased 2 and 50% after UCP-2 siRNA administration in control and diabetic animals respectively. Kidney function was unaffected by in vivo siRNA-mediated gene silencing of UCP-2. The reason for the lack of effect of reducing UCP-2 is presently unknown but may involve compensatory mitochondrial uncoupling by the adenosine nucleotide transporter. More... »

PAGES

217-223

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-4989-8_30

DOI

http://dx.doi.org/10.1007/978-1-4614-4989-8_30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007909824

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22879036


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