DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy? View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Bernard Salles , Patrick Calsou , Gladys Mirey

ABSTRACT

In the search for ways of sensitizing tumor cells to chemotherapy or radiotherapy, the inhibition of DNA repair has recently been proposed as a target of clinical interest. Ionizing radiations, as well as several antitumor drugs, induce the formation of DNA double-strand breaks (DSBs), that are highly damaging to the DNA, leading to cell death and genomic instability. DSBs are mainly repaired by the Nonhomologous End joining (NHEJ) process, in which DNA dependent protein kinase (DNA-PK) is the key complex. Consequently, specific DNA-PK inhibitors have been selected and evaluated for sensitizing cells to chemotherapy or radiotherapy. The choice of DNA-PK as a pharmacological target of interest in cancer treatment is discussed. More... »

PAGES

25-44

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  • Book

    TITLE

    Advances in DNA Repair in Cancer Therapy

    ISBN

    978-1-4614-4740-5
    978-1-4614-4741-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4614-4741-2_2

    DOI

    http://dx.doi.org/10.1007/978-1-4614-4741-2_2

    DIMENSIONS

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