Immune Co-signaling to Treat Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Margaret K. Callahan , Jedd D. Wolchok , James P. Allison , Padmanee Sharma

ABSTRACT

The past two decades have been marked by a growing understanding of the co-stimulatory and co-inhibitory pathways that are critical to the generation of an effective, well-regulated immune response. Capitalizing on an increasingly nuanced appreciation for the role that these molecules play in anti-tumor immune responses, a diversity of novel therapies to treat human cancers are being explored. The ground-breaking success of anti-CTLA-4 therapy in the treatment of advanced melanoma has set the stage for the clinical development of agents targeting a diversity of co-stimulatory and co-inhibitory molecules. Herein, we review the co-signaling molecules that regulate T cell activation with a focus on their potential role(s) in anti-tumor immune responses. Where available, pre-clinical and clinical studies evaluating the anti-tumor activity of agents targeting these molecules are presented. More... »

PAGES

211-280

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  • Book

    TITLE

    Cancer Immunotherapy

    ISBN

    978-1-4614-4731-3
    978-1-4614-4732-0

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4614-4732-0_8

    DOI

    http://dx.doi.org/10.1007/978-1-4614-4732-0_8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008319843


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