Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012-08-30

AUTHORS

Alberto d’Onofrio

ABSTRACT

Tumor progression is subject to modulation by the immune system. The immune system can eliminate tumors or keep them at a dormant equilibrium size, while some tumors escape immunomodulation and advance to malignancy. Herein, we discuss some aspects of immune evasion of dormant tumors from a theoretical biophysics point of view that can be modeled mathematically. We go on to analyze the mathematical system on multiple timescales. First, we consider a long timescale where tumor evasion is likely due to adaptive (and somewhat deterministic) immuno-editing. Then, we consider the temporal mesoscale and hypothesize that extrinsic noise could be a major factor in induction of immuno-evasion. Implications of immuno-evasive mechanisms for the outcome of immunotherapies are also discussed. In addition, we discuss the ideas that population level tumor dormancy may not be a quiescence phenomenon and that dormant tumors can, at least if modulated by the immune system, live a very active and noisy life! More... »

PAGES

111-143

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4614-1445-2_7

DOI

http://dx.doi.org/10.1007/978-1-4614-1445-2_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026382108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23143978


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