Fusion of Enveloped Viruses with Biological Membranes Fluorescence Dequenching Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Nor Chejanovsky , Ofer Nussbaum , Abraham Loyter , Robert Blumenthal

ABSTRACT

Enveloped virions penetrate eukaryotic cells by two alternative routes (Chop-pin and Scheid, 1980; White et al., 1983). Envelopes of viruses belonging to the paramyxovirus group fuse with cells’ plasma membranes at pH 7.4 and consequently microinject their content, the viral nucleocapsid, directly into the cell cytoplasm (Choppin and Scheid, 1980; Loyter and Volsky, 1982; White et al., 1983). A different way of entry has been described for most other enveloped virions such as those belonging to the orthomyxovirus, toga, rhabdo, and herpes groups. Such viruses are taken into cells by endocyticlike processes. Fusion of the viral envelopes with the endosomal or lysosomal membranes is triggered by the intraorganelle low-pH environment and leads to the introduction of the viral content into the intracellular space (Chopin and Scheid, 1980; White et al., 1983). Fusion of the pH-dependent virions with the plasma membrane can be triggered by lowering the pH of the medium containing the virus-associated cells. More... »

PAGES

415-56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-9359-7_13

DOI

http://dx.doi.org/10.1007/978-1-4613-9359-7_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025613936

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2577862


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